Strain-dependent disposition of inorganic arsenic in the mouse
MF Hughes, EM Kenyon, BC Edwards, CT Mitchell… - Toxicology, 1999 - Elsevier
Recent studies have suggested that polymorphisms in the methylation of inorganic arsenic
(iAs) exist in animals and humans. Methylation of iAs is an important step in the elimination …
(iAs) exist in animals and humans. Methylation of iAs is an important step in the elimination …
Arsenic (+ 3 oxidation state) methyltransferase and the inorganic arsenic methylation phenotype
J Li, SB Waters, Z Drobna, V Devesa, M Styblo… - Toxicology and applied …, 2005 - Elsevier
Inorganic arsenic is enzymatically methylated; hence, its ingestion results in exposure to the
parent compound and various methylated arsenicals. Both experimental and …
parent compound and various methylated arsenicals. Both experimental and …
Tissue distribution and urinary excretion of inorganic arsenic and its methylated metabolites in mice following acute oral administration of arsenate
EM Kenyon, LM Del Razo, MF Hughes - Toxicological Sciences, 2005 - academic.oup.com
The relationship of exposure dose and tissue concentration of parent chemical and
metabolites is a critical issue in cases where toxicity may be mediated by a metabolite or by …
metabolites is a critical issue in cases where toxicity may be mediated by a metabolite or by …
Disruption of the arsenic (+ 3 oxidation state) methyltransferase gene in the mouse alters the phenotype for methylation of arsenic and affects distribution and retention …
Z Drobna, H Naranmandura… - Chemical research in …, 2009 - ACS Publications
The arsenic (+ 3 oxidation state) methyltransferase (As3mt) gene encodes a 43 kDa protein
that catalyzes methylation of inorganic arsenic. Altered expression of AS3MT in cultured …
that catalyzes methylation of inorganic arsenic. Altered expression of AS3MT in cultured …
Mouse arsenic (+ 3 oxidation state) methyltransferase genotype affects metabolism and tissue dosimetry of arsenicals after arsenite administration in drinking water
Abstract Arsenic (+ 3 oxidation state) methyltransferase (As3mt) catalyzes methylation of
inorganic arsenic (iAs) producing a number of methylated arsenic metabolites. Although …
inorganic arsenic (iAs) producing a number of methylated arsenic metabolites. Although …
Dose-dependent urinary phenotype of inorganic arsenic methylation in mice with a focus on trivalent methylated metabolites
EA García-Montalvo, OL Valenzuela… - Toxicology …, 2011 - Taylor & Francis
Inorganic arsenic (iAs) exposure has been associated with the increased risk of various
forms of cancer and of non-cancerous diseases. Metabolic conversions of iAs that yield …
forms of cancer and of non-cancerous diseases. Metabolic conversions of iAs that yield …
Metabolism and disposition of arsenic species from controlled oral dosing with sodium arsenite in adult female CD-1 mice. I. Pilot study to determine dosing, analytical …
NC Twaddle, M Vanlandingham, MI Churchwell… - Food and Chemical …, 2018 - Elsevier
Arsenic (As) is ubiquitous in the earth's crust, with typical dietary intake in developed
countries< 1 μg/kg bw/d, and atypical groundwater exposures in developing countries …
countries< 1 μg/kg bw/d, and atypical groundwater exposures in developing countries …
Differential metabolism of inorganic arsenic in mice from genetically diverse Collaborative Cross strains
Mice have been frequently used to study the adverse effects of inorganic arsenic (iAs)
exposure in laboratory settings. Like humans, mice metabolize iAs to monomethyl-As (MAs) …
exposure in laboratory settings. Like humans, mice metabolize iAs to monomethyl-As (MAs) …
Tissue distribution and urinary excretion of inorganic arsenic and its methylated metabolites in C57BL6 mice following subchronic exposure to arsenate in drinking …
EM Kenyon, MF Hughes, BM Adair, JH Highfill… - Toxicology and applied …, 2008 - Elsevier
The relationship of exposure and tissue concentration of parent chemical and metabolites
over prolonged exposure is a critical issue for chronic toxicities mediated by metabolite (s) …
over prolonged exposure is a critical issue for chronic toxicities mediated by metabolite (s) …
Accumulation and metabolism of arsenic in mice after repeated oral administration of arsenate
MF Hughes, EM Kenyon, BC Edwards… - Toxicology and applied …, 2003 - Elsevier
Exposure to the human carcinogen inorganic arsenic (iAs) occurs daily. However, the
disposition of arsenic after repeated exposure is not well known. This study examined the …
disposition of arsenic after repeated exposure is not well known. This study examined the …