Objective To explore associations between changes of lower extremity function (LEF)
parameters over a 5‐year period and diffusion tensor imaging (DTI) parameters of white …

Background Higher levels of physical activity (PA) are known to be associated with better
white matter integrity measured by diffusion tensor imaging (DTI) in older adults in cross …

Background: Early pathological changes in white matter microstructure can be studied using
the diffusion tensor imaging (DTI). It is not only important to study these subtle pathological …

BACKGROUND Cross‐sectional associations have been found between frail individuals
and worse white matter (WM) integrity. However, the prospective association between WM …

Objective To evaluate the relationship of white matter hyperintensities (WMH) with decline in
lower extremity function (LEF) over approximately 3 years in dementia-free older adults with …

Skill retention is important for motor rehabilitation outcomes. Recent work has demonstrated
that delayed visuospatial memory performance may predict motor skill retention in older and …

Cognitive and physical activities can benefit cognition. However, knowledge about the
neurobiological mechanisms underlying these activity-induced cognitive benefits is still …

Background Age-related mobility limitations are debilitating and common. Cerebral white
matter hyperintensities (WMH) and conditions affecting other systems are known …

Mobility impairment in older persons is associated with brain white matter hyperintensities
(WMH), a common finding in magnetic resonance images and one established imaging …

Age-related deterioration of the white matter (WM), such as demyelination, is an important
mechanism of cognitive decline in healthy aging. Lifestyle factors can influence the course of …