[HTML][HTML] FTO promotes multiple myeloma progression by posttranscriptional activation of HSF1 in an m6A-YTHDF2-dependent manner

A Xu, J Zhang, L Zuo, H Yan, L Chen, F Zhao, F Fan… - Molecular Therapy, 2022 - cell.com
N 6-methyladenosine (m 6 A), as the most pervasive internal modification of eukaryotic
mRNA, plays a crucial role in various cancers, but its role in multiple myeloma (MM) …

[HTML][HTML] RNA N6-methyladenosine demethylase FTO promotes pancreatic cancer progression by inducing the autocrine activity of PDGFC in an m6A-YTHDF2 …

Z Tan, S Shi, J Xu, X Liu, Y Lei, B Zhang, J Hua… - Oncogene, 2022 - nature.com
Abstract RNA N6-methyladenosine (m6A) is an emerging regulator of mRNA modifications
and represents a novel player in tumorigenesis. Although it has functional significance in …

The FTO m6A demethylase inhibits the invasion and migration of prostate cancer cells by regulating total m6A levels

K Zhu, Y Li, Y Xu - Life Sciences, 2021 - Elsevier
Abstract Aims N6-Methyladenosine (m 6 A) is the most frequent posttranscriptional
modification and plays important roles in tumorigenesis and metastasis. The roles of fat …

[HTML][HTML] m6A demethylase FTO promotes hepatocellular carcinoma tumorigenesis via mediating PKM2 demethylation

J Li, L Zhu, Y Shi, J Liu, L Lin… - American journal of …, 2019 - ncbi.nlm.nih.gov
Abstract N6-methyladenosine (m6A) acts as the most common mRNA modification in
mammal cells. Fat Mass and Obesity-associated protein (FTO) is the firstly identified …

FTO-Dependent N6-Methyladenosine Modifications Inhibit Ovarian Cancer Stem Cell Self-Renewal by Blocking cAMP Signaling

H Huang, Y Wang, M Kandpal, G Zhao, H Cardenas… - Cancer research, 2020 - AACR
Abstract N 6-Methyladenosine (m6A) is the most abundant modification of mammalian
mRNAs. RNA methylation fine tunes RNA stability and translation, altering cell fate. The fat …

[HTML][HTML] m6A demethylase FTO promotes tumor progression via regulation of lipid metabolism in esophageal cancer

X Duan, L Yang, L Wang, Q Liu, K Zhang, S Liu, C Liu… - Cell & bioscience, 2022 - Springer
Background Epitranscriptomics studies have contributed greatly to the development of
research on human cancers. In recent years, N6-methyladenosine (m6A), an RNA …

[HTML][HTML] m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade

S Yang, J Wei, YH Cui, G Park, P Shah, Y Deng… - Nature …, 2019 - nature.com
Melanoma is one of the most deadly and therapy-resistant cancers. Here we show that N6-
methyladenosine (m6A) mRNA demethylation by fat mass and obesity-associated protein …

YTHDF2 promotes multiple myeloma cell proliferation via STAT5A/MAP2K2/p-ERK axis

Z Hua, R Wei, M Guo, Z Lin, X Yu, X Li, C Gu, Y Yang - Oncogene, 2022 - nature.com
Multiple myeloma (MM) is still incurable partially due to lacking effective therapeutic targets.
Aberrant N6-methyladenosine (m6A) RNA modification plays a vital role in many cancers …

Roles of N6‐Methyladenosine demethylase FTO in malignant tumors progression

QK Zheng, C Ma, I Ullah, K Hu, RJ Ma… - OncoTargets and …, 2021 - Taylor & Francis
In 2007, the fat mass and obesity-associated (FTO) gene was discovered initially to regulate
body mass index and obesity and was subsequently found to be the first mRNA N6 …

m6A RNA demethylase FTO promotes the growth, migration and invasion of pancreatic cancer cells through inhibiting TFPI-2

W Wang, Y He, LL Zhai, LJ Chen, LC Yao, L Wu… - Epigenetics, 2022 - Taylor & Francis
Pancreatic cancer (PC) is one of the most fatal cancers with a very poor prognosis. Here, we
found that N6-methyladenosine (m6A) RNA demethylase fat mass and obesity-related …