In recent decades, advances in biomedical research have helped save or lengthen the lives
of children around the world. With improved therapies, child and adolescent mortality rates …

Achieving proper balance between the social good that comes from performing research
that involves children and offering the appropriate level of protection to children who …

Should children be excluded from medical research? Some child rights activists argue that
no child should ever be used for research, while many physicians claim that health care for …

In this edited volume, a diverse group of scholars present and discuss challenging cases in
the field of pediatric research ethics. After years of debate and controversy, fundamental …

The critical need for pediatric research on drugs and biological products underscores the
responsibility to ensure that children are enrolled in clinical research that is both …

United States federal regulations for pediatric research with no prospect of direct benefit
restrict institutional review board (IRB) approval to procedures presenting: 1) no more than …

Guidelines around the world require children to provide assent for their participation in most
research studies. Yet, little further guidance is provided on how review committees should …

These guidelines are written for everyone involved in the planning, review, and conduct of
research with children. The Royal College of Paediatrics and Child Health's first guidelines …

This chapter reviews ways to design ethical research with children, from the early plans to
the final reports and dissemination. It considers the status of children in research design …

The unique vulnerability of children as research subjects came to light when Henry Beecher
1 published a landmark article in the New England Journal of Medicine entitled,“Ethics and …