Evaluating marginal genetic correlation of associated loci for complex diseases and traits between European and East Asian populations
Genome-wide association studies (GWASs) have successfully identified a large amount of
single-nucleotide polymorphisms associated with many complex phenotypes in diverse …
single-nucleotide polymorphisms associated with many complex phenotypes in diverse …
Leveraging trans-ethnic genetic risk scores to improve association power for complex traits in underrepresented populations
Trans-ethnic genome-wide association studies have revealed that many loci identified in
European populations can be reproducible in non-European populations, indicating …
European populations can be reproducible in non-European populations, indicating …
Power comparisons of methods for joint association analysis of multiple phenotypes
Abstract Background/Aims: Genome-wide association studies (GWAS) have identified many
variants that each affect multiple phenotypes, which suggests that pleiotropic effects on …
variants that each affect multiple phenotypes, which suggests that pleiotropic effects on …
Evaluating significance of European-associated index SNPs in the East Asian population for 31 complex phenotypes
Background Genome-wide association studies (GWASs) have identified many single-
nucleotide polymorphisms (SNPs) associated with complex phenotypes in the European …
nucleotide polymorphisms (SNPs) associated with complex phenotypes in the European …
SCOPA and META-SCOPA: software for the analysis and aggregation of genome-wide association studies of multiple correlated phenotypes
Background Genome-wide association studies (GWAS) of single nucleotide polymorphisms
(SNPs) have been successful in identifying loci contributing genetic effects to a wide range …
(SNPs) have been successful in identifying loci contributing genetic effects to a wide range …
[PDF][PDF] Localizing components of shared transethnic genetic architecture of complex traits from GWAS summary data
Despite strong transethnic genetic correlations reported in the literature for many complex
traits, the non-transferability of polygenic risk scores across populations suggests the …
traits, the non-transferability of polygenic risk scores across populations suggests the …
[PDF][PDF] Transethnic genetic-correlation estimates from summary statistics
The increasing number of genetic association studies conducted in multiple populations
provides an unprecedented opportunity to study how the genetic architecture of complex …
provides an unprecedented opportunity to study how the genetic architecture of complex …
[PDF][PDF] Local genetic correlation gives insights into the shared genetic architecture of complex traits
Although genetic correlations between complex traits provide valuable insights into
epidemiological and etiological studies, a precise quantification of which genomic regions …
epidemiological and etiological studies, a precise quantification of which genomic regions …
Theoretical and empirical quantification of the accuracy of polygenic scores in ancestry divergent populations
Polygenic scores (PGS) have been widely used to predict disease risk using variants
identified from genome-wide association studies (GWAS). To date, most GWAS have been …
identified from genome-wide association studies (GWAS). To date, most GWAS have been …
A statistical method for region-based meta-analysis of genome-wide association studies in genetically diverse populations
Genome-wide association studies (GWAS) have become the preferred experimental design
in exploring the genetic etiology of complex human traits and diseases. Standard SNP …
in exploring the genetic etiology of complex human traits and diseases. Standard SNP …