Biological pathways play important roles in the development of complex diseases, such as
cancers, which are multifactorial complex diseases that are usually caused by multiple …

Background Pathway analysis combining multiple types of high-throughput data, such as
genomics and proteomics, has become the first choice to gain insights into the pathogenesis …

Background Cancers, a group of multifactorial complex diseases, are generally caused by
mutation of multiple genes or dysregulation of pathways. Identifying biomarkers that can …

Cancer classification is the critical basis for patient-tailored therapy, while pathway analysis
is a promising method to discover the underlying molecular mechanisms related to cancer …

A disease phenotype generally reflects various pathobiological processes that interact in a
complex network. The highly interconnected nature of the human protein interaction network …

Over the years, network analysis has become a promising strategy for analysing complex
system, ie, systems composed of a large number of interacting elements. In particular …

Motivation Disease progression originates from the concept that an individual disease may
go through different changes as it evolves, and such changes can cause new diseases. It is …

Many statistical methods for pathway analysis have been used to identify pathways
associated with the disease along with biological factors such as genes and proteins …

A biological pathway is an ordered set of interactions between intracellular molecules
having collective activity that impacts cellular function, for example, by controlling metabolite …

In the era of biological omics, an essential issue is how to mine the important biological
information, including important signaling molecule patterns, signaling pathways, molecular …