It is desired to selectively kill tumor cells with little or no action on normal cells. Current
treatment options are associated with significant side effects including therapy with immune …

It is proposed that arachidonic acid (AA, 20: 4 n-6) and other polyunsaturated fatty acids
(PUFAs) in combination with immune check point inhibitors and tumor infiltrating …

Cancer is the second cause of death in developed countries. Surgery and radiotherapy are
widely used in the treatment of localized and attainable tumors. Chemotherapy and …

Lipids have been found to modulate tumor biology, including proliferation, survival, and
metastasis. With the new understanding of tumor immune escape that has developed in …

Rodent and clinical studies have documented that myeloid cell infiltration of tumors is
associated with neutrophilia, lymphocytopenia and poor patient outcomes. This contrasts …

Rodent and clinical studies have documented that myeloid cell infiltration of tumors is
associated with poor outcomes, neutrophilia and lymphocytopenia. This contrasts with …

Selective elimination of tumor cells with little or no effects on normal cells is desirable for the
treatment of cancer. Tumor cells are deficient in polyunsaturated fatty acids ([PUFAs] …

Results: PUFAs inhibited the growth of IMR-32 cells (EPA> DHA= AA> GLA= ALA> DGLA=
LA) significantly (p< 0.001) while prostaglandins were found to be not effective. Bleomycin …

Peritoneal macrophages (MØ) from mice become cytotoxic after incubation in lymphokine
(LK)‐rich supernatants of antigen‐stimulated spleen cell cultures. Tumoricidal activity is …

Lipids are a diverse class of biomolecules that have been implicated in cancer
pathophysiology and in an array of immune responses, making them potential targets for …