Following a decade of slow progress in improving the genetic prediction of common
diseases with tempered expectations about the ultimate predictive ability of polygenic risk …

The age of large-scale genome-wide association studies (GWAS) has provided us with an
unprecedented opportunity to evaluate the genetic liability of complex disease using …

Polygenic scores have recently been used to summarise genetic effects among an
ensemble of markers that do not individually achieve significance in a large-scale …

Clinical use of polygenic risk scores (PRS) will look very different to the more familiar
monogenic testing. Here we argue that despite these differences, most of the ethical, legal …

Polygenic risk scores (PRS) have attenuated cross-population predictive performance. As
existing genome-wide association studies (GWAS) have been conducted predominantly in …

Family history is the standard indirect measure of inherited susceptibility in clinical care,
whereas polygenic risk scores (PRSs) have more recently demonstrated potential for more …

An essential component of precision medicine is the ability to predict an individual's risk of
disease based on genetic and non-genetic factors. For complex traits and diseases …