Blood–brain barrier dysfunction in status epileptics: Mechanisms and role in epileptogenesis

E Swissa, Y Serlin, U Vazana, O Prager, A Friedman - Epilepsy & Behavior, 2019 - Elsevier
The blood–brain barrier (BBB), a unique anatomical and physiological interface between the
central nervous system (CNS) and the peripheral circulation, is essential for the function of …

Blood–brain barrier dysfunction and epilepsy: pathophysiologic role and therapeutic approaches

N Marchi, T Granata, C Ghosh, D Janigro - Epilepsia, 2012 - Wiley Online Library
The blood–brain barrier (BBB) is located within a unique anatomic interface and has
functional ramifications to most of the brain and blood cells. In the past, the BBB was …

Blood–brain barrier dysfunction, status epilepticus, seizures, and epilepsy: a puzzle of a chicken and egg?

A Friedman - Epilepsia, 2011 - Wiley Online Library
Status epilepticus is often associated with endothelial dysfunction and increased vessels
permeability. We discuss here the direct role of blood–brain barrier (BBB) dysfunction in …

Blood–brain barrier dysfunction, seizures and epilepsy

EA Van Vliet, E Aronica, JA Gorter - Seminars in cell & Developmental …, 2015 - Elsevier
The blood–brain barrier (BBB) is a dynamic and complex system which separates the brain
from the blood. It helps to maintain the homeostasis of the brain, which is essential for …

Blood‐brain barrier dysfunction, TGFβ signaling, and astrocyte dysfunction in epilepsy

UWE Heinemann, D Kaufer, A Friedman - Glia, 2012 - Wiley Online Library
Brain insults, including traumatic and ischemic injuries, are frequently followed by acute
seizures and delayed development of epilepsy. Dysfunction of the blood‐brain barrier (BBB) …

Status epilepticus, blood–brain barrier disruption, inflammation, and epileptogenesis

JA Gorter, EA van Vliet, E Aronica - Epilepsy & Behavior, 2015 - Elsevier
Over the last 15 years, attention has been focused on dysfunction of the cerebral vasculature
and inflammation as important players in epileptogenic processes, with a specific emphasis …

The neurovasculature as a target in temporal lobe epilepsy

Y Reiss, S Bauer, B David, K Devraj, E Fidan… - Brain …, 2023 - Wiley Online Library
The blood–brain barrier (BBB) is a physiological barrier maintaining a specialized brain
micromilieu that is necessary for proper neuronal function. Endothelial tight junctions and …

The roof is leaking and a storm is raging: repairing the blood–brain barrier in the fight against epilepsy

JA Gorter, E Aronica, EA Van Vliet - Epilepsy currents, 2019 - journals.sagepub.com
A large body of evidence that has accumulated over the past decade strongly supports the
role of both blood–brain barrier (BBB) dysfunction and perivascular inflammation in the …

The blood–brain barrier and epilepsy

E Oby, D Janigro - Epilepsia, 2006 - Wiley Online Library
During the past several years, there has been increasing interest in the role of the blood–
brain barrier (BBB) in epilepsy. Advances in neuroradiology have enhanced our ability to …

Blood–brain barrier dysfunction–induced inflammatory signaling in brain pathology and epileptogenesis

SY Kim, M Buckwalter, H Soreq, A Vezzani… - Epilepsia, 2012 - Wiley Online Library
The protection of the brain from blood‐borne toxins, proteins, and cells is critical to the
brain's normal function. Accordingly, a compromise in the blood–brain barrier (BBB) function …