The discovery of immune checkpoints and subsequent clinical development of checkpoint
inhibitors have revolutionized the field of oncology. The durability of the antitumor immune …

Immune checkpoint therapy has started a revolution in the field of oncology. The concept
that the immune system plays a critical role in antitumor responses, which has been around …

Simple Summary Immune checkpoint inhibitors (ICIs) are the most mature treatment of
immunotherapy and have changed the mode of cancer treatment. Recent studies showed …

Checkpoint blockade has formally demonstrated that reactivating anti-tumor immune
responses can regress tumors. However, this only occurs in a fraction of patients …

Immune checkpoint inhibitors, including those targeting the programmed cell death
1/programmed cell death ligand 1 and cytotoxic T lymphocyte antigen 4 pathways, are …

Current immune checkpoint-modulating agents have demonstrated clinical efficacy in
certain tumor types, particularly those with a high burden of tumor-specific neoantigens, high …

Immune checkpoint inhibitor therapy has revolutionized the field of cancer immunotherapy.
Even though it has shown a durable response in some solid tumors, several patients do not …

Immunotherapy has changed the landscape of cancer treatment. Checkpoint blockade
therapies unleash breaks in the immune system and induce long-lasting responses …

Immune responses are tightly regulated via signaling through numerous co-stimulatory and
co-inhibitory molecules. Exploitation of these immune checkpoint pathways is one of the …

In the last 5 years, immune checkpoint antibodies have become established as anticancer
agents for various types of cancer. These antibody drugs, namely cytotoxic T‐lymphocyte …