[HTML][HTML] Nanobodies: prospects of expanding the gamut of neutralizing antibodies against the novel coronavirus, SARS-CoV-2

R Konwarh - Frontiers in immunology, 2020 - frontiersin.org
With more than 6.9 M confirmed cases and~ 400 K deaths as on June 8, 2020 (1), COVID-
19, ushered in by the SARS-CoV-2 has projected itself as a microscopic-holocaust, much …

[PDF][PDF] A therapeutic non-self-reactive SARS-CoV-2 antibody protects from lung pathology in a COVID-19 hamster model

J Kreye, SM Reincke, HC Kornau, E Sánchez-Sendin… - Cell, 2020 - cell.com
The emergence of SARS-CoV-2 led to pandemic spread of coronavirus disease 2019
(COVID-19), manifesting with respiratory symptoms and multi-organ dysfunction. Detailed …

Applications of nanobodies in the prevention, detection, and treatment of the evolving SARS-CoV-2

W Wang, Y Hu, B Li, H Wang, J Shen - Biochemical Pharmacology, 2023 - Elsevier
Global health and economy are deeply influenced by the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) and its newly emerging variants. Nanobodies with nanometer …

Antibodies to combat viral infections: development strategies and progress

G Pantaleo, B Correia, C Fenwick, VS Joo… - Nature Reviews Drug …, 2022 - nature.com
Monoclonal antibodies (mAbs) are appealing as potential therapeutics and prophylactics for
viral infections owing to characteristics such as their high specificity and their ability to …

[PDF][PDF] Extremely potent human monoclonal antibodies from COVID-19 convalescent patients

E Andreano, E Nicastri, I Paciello, P Pileri… - Cell, 2021 - cell.com
Human monoclonal antibodies are safe, preventive, and therapeutic tools that can be rapidly
developed to help restore the massive health and economic disruption caused by the …

[PDF][PDF] The antigenic anatomy of SARS-CoV-2 receptor binding domain

W Dejnirattisai, D Zhou, HM Ginn, HME Duyvesteyn… - Cell, 2021 - cell.com
Antibodies are crucial to immune protection against SARS-CoV-2, with some in emergency
use as therapeutics. Here, we identify 377 human monoclonal antibodies (mAbs) …

[HTML][HTML] Neutralizing monoclonal antibodies for COVID-19 treatment and prevention

JP Jaworski - biomedical journal, 2021 - Elsevier
The SARS-CoV-2 pandemic has caused unprecedented global health and economic crises.
Several vaccine approaches and repurposed drugs are currently under evaluation for safety …

[HTML][HTML] Broadly neutralizing antibodies to SARS-CoV-2 provide novel insights into the neutralization of variants and other human coronaviruses

P Bajpai, V Singh, A Chandele… - Frontiers in cellular and …, 2022 - frontiersin.org
Seven coronaviruses are known to cause infection/disease in humans. Of these, human
coronavirus (HCoV)-229E and HCoV-NL63 are alphacoronaviruses (α-CoVs), whereas …

Isolation of an escape-resistant SARS-CoV-2 neutralizing nanobody from a novel synthetic nanobody library

D Dormeshkin, M Shapira, S Dubovik… - Frontiers in …, 2022 - frontiersin.org
The COVID− 19 pandemic not only resulted in a global crisis, but also accelerated vaccine
development and antibody discovery. Herein we report a synthetic humanized VHH library …

[HTML][HTML] Protective roles and protective mechanisms of neutralizing antibodies against SARS-CoV-2 infection and their potential clinical implications

EC Abebe, TA Dejenie - Frontiers in immunology, 2023 - frontiersin.org
Neutralizing antibodies (NAbs) are central players in the humoral immunity that defends the
body from SARS-CoV-2 infection by blocking viral entry into host cells and neutralizing their …