Abstract As of June 2020, Coronavirus Disease 2019 (COVID-19) has killed an estimated
440 000 people worldwide, 74% of whom were aged≥ 65 years, making age the most …

Abstract Background Since December 2019, an outbreak of the Corona Virus disease 2019
(COVID‐19) caused by severe acute respiratory syndrome coronavirus (SARS‐CoV‐2) in …

Advanced age is a key predictor of severe COVID-19. To gain insight into this relationship,
we used the rhesus macaque model of SARS-CoV-2 infection. Eight older and eight …

Age is a risk factor for coronavirus disease 2019 (COVID-19)-associated morbidity and
mortality in humans; hence, in this study, we compared the course of severe acute …

In late 2019, an outbreak of a severe respiratory disease caused by an emerging
coronavirus, SARS-CoV-2, resulted in high morbidity and mortality in infected humans …

Understanding the pathological features of severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) infection in an animal model is crucial for the treatment of coronavirus …

Older individuals are at higher risk of SARS-CoV-2 infection and severe outcomes, but the
underlying mechanisms are incompletely understood. In addition, how age modulates SARS …

Morbidity and mortality in response to SARS-CoV-2 infection are significantly elevated in
people of advanced age. To understand the underlying biology of this phenotype, we utilize …

In this study, peripheral blood mononuclear cells from young and old patients with COVID-
19 were examined phenotypically, transcriptionally and functionally to reveal age-, time-and …

Non-human primate models will expedite therapeutics and vaccines for coronavirus disease
2019 (COVID-19) to clinical trials. Here, we compare acute severe acute respiratory …