Alzheimer's disease (AD), the most common form of dementia, is characterized by the
progressive loss of neurons and synapses, and by extracellular deposits of amyloid‐β (Aβ) …

Fundamental questions on the pathogenesis of Alzheimer's disease (AD) are how nontoxic,
soluble amyloid β‐protein (Aβ) is converted to its toxic, aggregated form and how functional …

Recent results implicating cholesterol metabolism in the pathophysiology of Alzheimer's
disease (AD) bring cholesterol to the forefront of AD research. Research from genetics …

Epidemiological, animal, and cellular studies suggest that abnormalities in cholesterol
metabolism are important in the pathogenesis of Alzheimer's disease (AD), potentially by …

Cholesterol has been implicated in the pathogenesis of Alzheimer's disease, both through
intracellular effects, and through an extracellular effect due to its physical interaction with …

The accumulation and aggregation of the amyloid-β peptide (Aβ) in the brain are important
contributing factors to Alzheimer's disease (AD). Consequently, blocking the generation of …

The implication that cholesterol plays an essential role in the pathogenesis of Alzheimer's
disease (AD) is based on the 1993 finding that the presence of apolipoprotein E (apoE) …

In recent decades, the impairment of cholesterol metabolism in the pathogenesis of
Alzheimer's disease (AD) has been intensively investigated, and it has been recognized to …

Recent epidemiological, clinical, and experimental data suggest that cholesterol may play a
role in Alzheimer's disease (AD). We have recently shown that cholesterolemia has a …

Cholesterol has been implicated in the pathogenesis of amyloid plaques in Alzheimer's
disease (AD) and in the formation of neurofibrillary pathology in Niemann‐Pick disease …