[HTML][HTML] Repurposing of drugs for combined treatment of COVID-19 cytokine storm using machine learning

MR Gantla, IF Tsigelny, VL Kouznetsova - Medicine in Drug Discovery, 2023 - Elsevier
Severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) induced cytokine storm is
the major cause of COVID-19 related deaths. Patients have been treated with drugs that …

Machine learning identifies molecular regulators and therapeutics for targeting SARS‐CoV2‐induced cytokine release

M Chan, S Vijay, J McNevin, MJ McElrath… - Molecular systems …, 2021 - embopress.org
Abstract Although 15–20% of COVID‐19 patients experience hyper‐inflammation induced
by massive cytokine production, cellular triggers of this process and strategies to target them …

[HTML][HTML] In silico synergistic drug repurposing for combating novel coronavirus (COVID-19) outbreaks

M Kim, YB Kim - 2020 - europepmc.org
As the number of novel coronavirus (COVID-19) cases continues to rise, there is a global
need for rapid drug development. In this study, we propose a systems pharmacology …

Methotrexate inhibition of SARS-CoV-2 entry, infection and inflammation revealed by bioinformatics approach and a hamster model

YT Chen, YH Chang, N Pathak, SC Tzou… - Frontiers in …, 2022 - frontiersin.org
Background Drug repurposing is a fast and effective way to develop drugs for an emerging
disease such as COVID-19. The main challenges of effective drug repurposing are the …

Staying ahead of the game: how SARS-CoV-2 has accelerated the application of machine learning in pandemic management

AH Williams, CG Zhan - BioDrugs, 2023 - Springer
In recent years, machine learning (ML) techniques have garnered considerable interest for
their potential use in accelerating the rate of drug discovery. With the emergence of the …

SARS‐CoV‐2–host proteome interactions for antiviral drug discovery

X Liu, S Huuskonen, T Laitinen, T Redchuk… - Molecular Systems …, 2021 - embopress.org
Abstract Treatment options for COVID‐19, caused by SARS‐CoV‐2, remain limited.
Understanding viral pathogenesis at the molecular level is critical to develop effective …

Protein–protein interaction network for the identification of new targets against novel Coronavirus

S Kumar - In Silico Modeling of Drugs Against Coronaviruses …, 2021 - Springer
Abstract SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) is a novel virus in
the family of Coronaviridae. The virus causes COVID-19, an infectious disease. SARS-CoV …

Virtual screening FDA approved drugs against multiple targets of SARS‐CoV‐2

H Liang, L Zhao, X Gong, M Hu… - Clinical and translational …, 2021 - Wiley Online Library
The outbreak of the novel coronavirus severe acute respiratory syndrome‐coronavirus 2
(SARS‐CoV‐2), the causative agent of coronavirus disease 2019 (COVID‐19) respiratory …

Molecular docking studies for protein-targeted drug development in SARS-CoV-2

AD Nurhan, MA Gani, S Maulana… - Letters in Drug …, 2022 - ingentaconnect.com
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a
global pandemic and emergency. Currently, there is no therapeutic agent that has been …

Repurposing novel therapeutic candidate drugs for coronavirus disease-19 based on protein-protein interaction network analysis

M Adhami, B Sadeghi, A Rezapour, AA Haghdoost… - BMC …, 2021 - Springer
Background The coronavirus disease-19 (COVID-19) emerged in Wuhan, China and rapidly
spread worldwide. Researchers are trying to find a way to treat this disease as soon as …