Publisher Summary This chapter focuses on various molecules involved in the regulation of
metanephrogenesis. The chapter assigns specific cellular roles to molecules based on their …

Of the nine known PAX genes, only two (PAX2 and PAX8) are expressed in the developing
kidney. Genetic evidence in mice and humans indicates that PAX2 plays a critical role in …

Pax genes are associated with a variety of developmental mutations in mouse and man that
are gene dosage sensitive, or haploinsufficient. The Pax2 gene encodes a DNA binding …

The conversion of mesenchyme to epithelium during the embryonic development of the
mammalian kidney requires reciprocal inductive interactions between the ureter and the …

Abstract Specification of the intermediate mesoderm and the epithelial derivatives that will
make the mammalian kidney depends on the concerted action of many transcription factors …

Pax2 has been identified as a key regulatory protein associated with renal developmental
malformations. The purpose of this study was to determine whether Pax2 protein expression …

Pax genes are important regulators of kidney development. In the mouse, homozygous Pax2
inactivation results in renal agenesis, a phenotype that has largely precluded the analysis of …

The Pax2 gene encodes a DNA binding protein with multiple functions in the developing
intermediate mesoderm and urogenital tract. Loss of Pax2 in mice results in the complete …

Re-expression of the developmental gene Pax-2 during experimental acute tubular necrosis
in mice. Background The transcription factor Pax-2 is known to play a key regulatory role …

The development of a complex tissue from a few simple precursor cells requires the precise
activation and repression of tissue‐specific genes that determine cell lineages, tissue …