Proteomics and metabolomics in kidney disease, including insights into etiology, treatment, and prevention

RF Dubin, EP Rhee - Clinical Journal of the American Society of …, 2020 - journals.lww.com
In this review of the application of proteomics and metabolomics to kidney disease research,
we review key concepts, highlight illustrative examples, and outline future directions. The …

Metabolomics approaches for the diagnosis and understanding of kidney diseases

H Abbiss, GL Maker, RD Trengove - Metabolites, 2019 - mdpi.com
Diseases of the kidney are difficult to diagnose and treat. This review summarises the
definition, cause, epidemiology and treatment of some of these diseases including chronic …

The tissue proteome in the multi-omic landscape of kidney disease

MM Rinschen, J Saez-Rodriguez - Nature Reviews Nephrology, 2021 - nature.com
Kidney research is entering an era of 'big data'and molecular omics data can provide
comprehensive insights into the molecular footprints of cells. In contrast to transcriptomics …

Metabolomics in the study of kidney diseases

RH Weiss, K Kim - Nature Reviews Nephrology, 2012 - nature.com
Metabolomics—the nontargeted measurement of all metabolites produced by the body—is
beginning to show promise in both biomarker discovery and, in the form of …

Metabolomic signatures of chronic kidney disease of diverse etiologies in the rats and humans

ZH Zhang, H Chen, ND Vaziri, JR Mao… - Journal of proteome …, 2016 - ACS Publications
Chronic kidney disease (CKD) has emerged as a major public health problem worldwide. It
frequently progresses to end-stage renal disease, which is related to very high cost and …

Metabolomics in chronic kidney disease

YY Zhao - Clinica chimica acta, 2013 - Elsevier
Chronic kidney disease (CKD) represents a major challenge to public healthcare.
Traditional clinical biomarkers of renal function (blood urea nitrogen and serum creatinine) …

Chronic kidney disease: biomarker diagnosis to therapeutic targets

YN Wang, SX Ma, YY Chen, L Chen, BL Liu, QQ Liu… - Clinica Chimica …, 2019 - Elsevier
Chronic kidney disease (CKD), characterized as renal dysfunction, is recognized as a major
public health problem with high morbidity and mortality worldwide. Unfortunately, there are …

Metabolomics in diabetic kidney disease: unraveling the biochemistry of a silent killer

M Darshi, B Van Espen, K Sharma - American journal of nephrology, 2016 - karger.com
The development of new therapies for chronic diseases, such as diabetic kidney disease
(DKD), will continue to be hampered by lack of sufficient biomarkers that will provide insights …

Assessment of metabolomic and proteomic biomarkers in detection and prognosis of progression of renal function in chronic kidney disease

E Nkuipou-Kenfack, F Duranton, N Gayrard, A Argiles… - PloS one, 2014 - journals.plos.org
Chronic kidney disease (CKD) is part of a number of systemic and renal diseases and may
reach epidemic proportions over the next decade. Efforts have been made to improve …

High-throughput metabolomics and diabetic kidney disease progression: evidence from the chronic renal insufficiency (CRIC) study

J Zhang, T Fuhrer, H Ye, B Kwan… - American journal of …, 2022 - karger.com
Introduction: Metabolomics could offer novel prognostic biomarkers and elucidate
mechanisms of diabetic kidney disease (DKD) progression. Via metabolomic analysis of …