Mechanisms of cell death in Alzheimer disease—immunopathology

PL McGeer, EG McGeer - Alzheimer's Disease—From Basic Research to …, 1998 - Springer
Lesions in such chronic neurodegenerative disorders as Alzheimer disease, Parkinson
disease, the parkinsonism dementia complex of Guam and amyotrophic lateral sclerosis …

The importance of inflammatory mechanisms in Alzheimer disease

EG McGeer, PL McGeer - Experimental gerontology, 1998 - Elsevier
Lesions in such chronic neurodegenerative disorders as Alzheimer disease (AD), Parkinson
disease, the parkinsonism dementia complex of Guam, and amyotrophic lateral sclerosis …

Glial Cell Reactions in Neurodegenerative Diseases Pathophysiology and Therapeutic Interventions

PL McGeer, EG McGeer - Alzheimer Disease & Associated …, 1998 - journals.lww.com
A variety of proteins known to be involved in inflammatory processes are associated with
lesions in chronic neurodegenerative disorders such as Alzheimer disease (AD) …

Inflammatory mechanisms in Alzheimer's disease: implications for therapy.

PS Aisen, KL Davis - The American journal of psychiatry, 1994 - europepmc.org
Objective The purpose of this article is to review evidence that inflammatory and immune
mechanisms are important in the pathophysiology of Alzheimer's disease and to suggest …

The pathological cascade of Alzheimer's disease: the role of inflammation and its therapeutic implications.

JJ Hoozemans, R Veerhuis, AJ Rozemuller… - Drugs of Today …, 2002 - europepmc.org
Alzheimer's disease is a chronic neurodegenerative disease causing progressive
impairment of memory and other cognitive functions. A number of sequential events are …

Alzheimer's disease: a review concerning immune response and microischemia

RL Chorsky, F Yaghmai, WD Hill, EG Stopa - Medical hypotheses, 2001 - Elsevier
Alzheimer's disease (AD), as we think of it today, is the idiopathic progressive loss of
cognitive function over a period of several years. The risk of late onset dementia increases …

Neuroimmune mechanisms in Alzheimer disease pathogenesis

PL McGeer, J Rogers, EG McGeer - Alzheimer Disease & …, 1994 - journals.lww.com
Lesions in Alzheimer disease are characterized by the assembly of a variety of cells and
proteins associated with the immune system. Activated microglia express high levels of …

Alzheimer's disease:: An inflammatory disease?

K Fassbender, C Masters, K Beyreuther - Neurobiology of Aging, 2000 - Elsevier
Alzheimer's disease (AD) is the most common form of dementia. More alarmingly, because
of longer life-spans, the number of affected persons is expected to triple over the next 50 …

The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases

PL McGeer, EG McGeer - Brain Research Reviews, 1995 - Elsevier
Cultured brain cells are capable of generating many molecules associated with
inflammatory and immune functions. They constitute the endogenous immune response …

Systemic inflammation and A lzheimer's disease

C Holmes - Neuropathology and applied neurobiology, 2013 - Wiley Online Library
There is a great deal of evidence suggesting an important role for systemic inflammation in
the pathogenesis of A lzheimer's disease. The role of systemic inflammation, and indeed …