Abstract The World Health Organization has declared the emergence of antibiotic resistance
to be a global threat to human health. Broad-host-range plasmids have a key role in causing …

Multidrug resistant bacterial pathogens have become a serious global human health threat,
and conjugative plasmids are important drivers of the rapid spread of resistance to last …

Antibiotic resistance encoded on plasmids is a pressing global health problem. Predicting
which plasmids spread in the long term remains very challenging, even though some key …

Plasmid acquisition is an important mechanism of rapid adaptation and niche expansion in
prokaryotes. Positive selection for plasmid-coded functions is a major driver of plasmid …

The global dissemination of plasmids encoding antibiotic resistance represents an urgent
issue for human health and society. While the fitness costs for host cells associated with …

Horizontal gene transfer mediated by broad-host-range plasmids is an important mechanism
of antibiotic resistance spread. While not all bacteria maintain plasmids equally well …

Antibiotic resistance consists of a dynamic web. In this review, we describe the path by
which different antibiotic residues and antibiotic resistance genes disseminate among …

The evolutionary pressures that determine the location (chromosomal or plasmid-borne) of
bacterial genes are not fully understood. We investigate these pressures through …

Promiscuous plasmids replicate in a wide range of bacteria and therefore play a key role in
the dissemination of various host-beneficial traits, including antibiotic resistance. Despite the …

Plasmids mediate the horizontal transmission of genetic information between bacteria,
facilitating their adaptation to multiple environmental conditions. An especially important …