Abstract 3D-printed biofunctional scaffolds have promising applications in bone tissue
regeneration. However, the development of bioinks with rapid internal vascularization …

The crosstalk between osteoblasts and endothelial cells is critical for bone vascularization
and regeneration. Here, we used a coaxial 3D bioprinting method to directly print an osteon …

Natural bone is a highly vascularized tissue that relies on the vasculature for blood and
nutrients supply to maintain skeletal integrity. Inadequacy of neovascularization may …

Abstract 3D printed scaffolds hold promising perspective for bone tissue regeneration.
Inspired by process of bone development stage, 3D printed scaffolds with rapid internal …

Abstract Three-dimensional (3D) bioprinting holds promise for precise repair of bone
defects, but rapid formation of effective vascularized tissue by 3D-printed construct is still a …

Acellular soft hydrogels are not ideal for hard tissue engineering given their poor
mechanical stability, however, in combination with cellular components offer significant …

Regeneration the critical-sized bone defects remains a great challenge to clinical therapy
due to the inflammatory microenvironment and lack of stem cells in the region of the bone …

Vascularization is a fundamental prerequisite for large bone construct development and
remains one of the main challenges of bone tissue engineering. Our current study presents …

Abstract 3D printing/bioprinting are promising techniques to fabricate scaffolds with well
controlled and patient-specific structures and architectures for bone tissue engineering. In …

For 3D bioprinted tissues to be scaled-up to clinically relevant sizes, effective
prevascularisation strategies are required to provide the necessary nutrients for normal …