Genome-wide prediction of conserved and nonconserved enhancers by histone acetylation patterns
Comparative genomic studies have been useful in identifying transcriptional regulatory
elements in higher eukaryotic genomes, but many important regulatory elements cannot be …
elements in higher eukaryotic genomes, but many important regulatory elements cannot be …
Distinct and predictive histone lysine acetylation patterns at promoters, enhancers, and gene bodies
In eukaryotic cells, histone lysines are frequently acetylated. However, unlike modifications
such as methylations, histone acetylation modifications are often considered redundant. As …
such as methylations, histone acetylation modifications are often considered redundant. As …
Comprehensive benchmarking reveals H2BK20 acetylation as a distinctive signature of cell-state-specific enhancers and promoters
V Kumar, NA Rayan, M Muratani, S Lim… - Genome …, 2016 - genome.cshlp.org
Although over 35 different histone acetylation marks have been described, the
overwhelming majority of regulatory genomics studies focus exclusively on H3K27ac and …
overwhelming majority of regulatory genomics studies focus exclusively on H3K27ac and …
Active chromatin domains are defined by acetylation islands revealed by genome-wide mapping
The identity and developmental potential of a human cell is specified by its epigenome that
is largely defined by patterns of chromatin modifications including histone acetylation. Here …
is largely defined by patterns of chromatin modifications including histone acetylation. Here …
Core promoter structure and genomic context reflect histone 3 lysine 9 acetylation patterns
Background Histone modifications play an important role in gene regulation. Acetylation of
histone 3 lysine 9 (H3K9ac) is generally associated with transcription initiation and unfolded …
histone 3 lysine 9 (H3K9ac) is generally associated with transcription initiation and unfolded …
Acetylation of histone H2B marks active enhancers and predicts CBP/p300 target genes
Chromatin features are widely used for genome-scale mapping of enhancers. However,
discriminating active enhancers from other cis-regulatory elements, predicting enhancer …
discriminating active enhancers from other cis-regulatory elements, predicting enhancer …
Epigenetic signatures distinguish multiple classes of enhancers with distinct cellular functions
Epigenetic regulation of gene enhancer elements is important for establishing and
maintaining the identity of cells. Gene enhancer elements are thought to exist in either active …
maintaining the identity of cells. Gene enhancer elements are thought to exist in either active …
Histone H3 globular domain acetylation identifies a new class of enhancers
Histone acetylation is generally associated with active chromatin, but most studies have
focused on the acetylation of histone tails. Various histone H3 and H4 tail acetylations mark …
focused on the acetylation of histone tails. Various histone H3 and H4 tail acetylations mark …
H4K16 acetylation marks active genes and enhancers of embryonic stem cells, but does not alter chromatin compaction
GCA Taylor, R Eskeland, B Hekimoglu-Balkan… - Genome …, 2013 - genome.cshlp.org
Compared with histone H3, acetylation of H4 tails has not been well studied, especially in
mammalian cells. Yet, H4K16 acetylation is of particular interest because of its ability to …
mammalian cells. Yet, H4K16 acetylation is of particular interest because of its ability to …
Histone H4 lysine 20 acetylation is associated with gene repression in human cells
JY Kaimori, K Maehara, Y Hayashi-Takanaka… - Scientific reports, 2016 - nature.com
Histone acetylation is generally associated with gene activation and chromatin
decondensation. Recent mass spectrometry analysis has revealed that histone H4 lysine 20 …
decondensation. Recent mass spectrometry analysis has revealed that histone H4 lysine 20 …