Leveraging the biology of adversity to address the roots of disparities in health and development

JP Shonkoff - Proceedings of the National Academy of …, 2012 - National Acad Sciences
Extensive evidence that personal experiences and environmental exposures are embedded
biologically (for better or for worse) and the cumulative knowledge of more than four …

Capitalizing on advances in science to reduce the health consequences of early childhood adversity

JP Shonkoff - JAMA pediatrics, 2016 - jamanetwork.com
Advances in biology are providing deeper insights into how early experiences are built into
the body with lasting effects on learning, behavior, and health. Numerous evaluations of …

Genes, environments, and time: the biology of adversity and resilience

WT Boyce, P Levitt, FD Martinez, BS McEwen… - …, 2021 - publications.aap.org
Exposures to adverse environments, both psychosocial and physicochemical, are prevalent
and consequential across a broad range of childhood populations. Such adversity …

Prevent, screen, heal: Collective action to fight the toxic effects of early life adversity

NB Harris, SS Marques, D Oh, M Bucci… - Academic …, 2017 - academicpedsjnl.net
EXPOSURE TO ADVERSE Childhood Experiences (ACEs), including abuse, neglect,
household dysfunction, and other early life adversities, have been associated with negative …

Leveraging the biology of adversity and resilience to transform pediatric practice

JP Shonkoff, WT Boyce, P Levitt, FD Martinez… - …, 2021 - publications.aap.org
Advances in science are fundamentally changing the way we understand how inextricable
interactions among genetic predispositions, physical and social environments, and …

The lifelong effects of early childhood adversity and toxic stress

JP Shonkoff, AS Garner… - …, 2012 - publications.aap.org
This Technical Report was retired November 2021. Advances in fields of inquiry as diverse
as neuroscience, molecular biology, genomics, developmental psychology, epidemiology …

Beyond cumulative risk: A dimensional approach to childhood adversity

KA McLaughlin, MA Sheridan - Current directions in …, 2016 - journals.sagepub.com
Children who have experienced environmental adversity—such as abuse, neglect, or
poverty—are more likely to develop physical and mental health problems, perform poorly at …

Early childhood adversity, toxic stress, and the role of the pediatrician: translating developmental science into lifelong health

Committee on Psychosocial Aspects of Child and … - …, 2012 - publications.aap.org
Advances in a wide range of biological, behavioral, and social sciences are expanding our
understanding of how early environmental influences (the ecology) and genetic …

Measuring early life adversity: A dimensional approach

IS Berman, KA McLaughlin, N Tottenham… - Development and …, 2022 - cambridge.org
Exposure to adversity in childhood is associated with elevations in numerous physical and
mental health outcomes across the life course. The biological embedding of early …

Thinking clearly about biology and childhood adversity: Next steps for continued progress

SD Pollak, KE Smith - Perspectives on Psychological …, 2021 - journals.sagepub.com
In a previous Perspectives article, we described conceptual problems that pose challenges
for research on the effects of childhood adversity and offered promising directions for future …