Senescence and epigenetic alterations are two important hallmarks of cellular aging. During
aging, cells subjected to stress undergo many cycles of damage and repair before finally …

Aging is the result of a gradual functional decline at the cellular, and ultimately, organismal
level, resulting in an increased risk of developing a variety of chronic illnesses, such as …

Skin aging has long been considered a purely cosmetic problem. However, as life
expectancy increases, skin aging is taking on a functional dimension that goes beyond …

The skin is the largest organ and has a key protective role. Similar to any other tissue, the
skin is influenced not only by intrinsic/chronological aging, but also by extrinsic aging …

Aging of the skin is evidenced by increased wrinkles, age spots, dryness, and thinning with
decreased elasticity. Extrinsic and intrinsic factors including UV, pollution, and inflammation …

Aging is a complex process characterized by an ongoing decline in physiological functions,
leading to degenerative diseases and an increased probability of death. Cellular …

Despite the growing interest by researchers into cellular senescence, a hallmark of cellular
aging, its role in human skin remains equivocal. The skin is the largest and most accessible …

The number of senescent cells in the skin is increasing with age. Numerous studies have
attempted to elucidate the role of these cells in normal aging of the skin as well as in age …

Background: As the largest organ in the human body, the skin is continuously exposed to
intrinsic and extrinsic stimuli that impact its functionality and morphology with aging. Skin …

Beyond the palliative reach of today's medicines, medical therapies of tomorrow aim to treat
the root cause of age-related diseases by targeting fundamental aging mechanisms. Pillars …