Association of Nirmatrelvir/Ritonavir Treatment with Long COVID Symptoms in an Online Cohort of Non-Hospitalized Individuals Experiencing Breakthrough SARS …

MS Durstenfeld, MJ Peluso, F Lin, ND Peyser, C Isasi… - medRxiv, 2023 - medrxiv.org
Background Oral nirmatrelvir/ritonavir is a treatment for COVID-19, but whether treatment
during the acute phase reduces the risk of developing Long COVID is unknown. Methods …

Association of nirmatrelvir for acute SARS‐CoV‐2 infection with subsequent Long COVID symptoms in an observational cohort study

MS Durstenfeld, MJ Peluso, F Lin… - Journal of Medical …, 2024 - Wiley Online Library
Oral nirmatrelvir/ritonavir is approved as treatment for acute COVID‐19, but the effect of
treatment during acute infection on risk of Long COVID is unknown. We hypothesized that …

Nirmatrelvir/ritonavir and risk of long COVID symptoms: a retrospective cohort study

S Congdon, Z Narrowe, N Yone, J Gunn, Y Deng… - Scientific reports, 2023 - nature.com
We conducted a retrospective cohort study to assess whether treatment with
nirmatrelvir/ritonavir was associated with a reduced risk of long COVID. We enrolled 500 …

Real-world effectiveness of nirmatrelvir/ritonavir use for COVID-19: A population-based cohort study in Ontario, Canada

KL Schwartz, J Wang, M Tadrous, BJ Langford… - medRxiv, 2022 - medrxiv.org
Background Our objective was to evaluate the real world effectiveness of
nirmatrelvir/ritonavir to prevent severe COVID-19 while Omicron and its subvariants …

[HTML][HTML] Nirmatrelvir plus ritonavir for early COVID-19 and hospitalization in a large US health system

S Dryden-Peterson, A Kim, AY Kim, EC Caniglia… - medRxiv, 2022 - ncbi.nlm.nih.gov
Background: In the EPIC-HR trial, nirmatrelvir plus ritonavir led to an 88% reduction in
hospitalization or death among unvaccinated outpatients with early COVID-19. Clinical …

Nirmatrelvir for vaccinated or unvaccinated adult outpatients with Covid-19

J Hammond, RJ Fountaine, C Yunis… - … England Journal of …, 2024 - Mass Medical Soc
Background Nirmatrelvir in combination with ritonavir is an antiviral treatment for mild-to-
moderate coronavirus disease 2019 (Covid-19). The efficacy of this treatment in patients …

Symptoms, Viral Loads, and Rebound Among COVID-19 Outpatients Treated With Nirmatrelvir/Ritonavir Compared With Propensity Score–Matched Untreated …

SE Smith-Jeffcoat, JE Biddle, HK Talbot… - Clinical Infectious …, 2024 - academic.oup.com
Abstract Background Nirmatrelvir/ritonavir (N/R) reduces severe outcomes from coronavirus
disease 2019 (COVID-19); however, rebound after treatment has been reported. We …

Nirmatrelvir and the risk of post-acute sequelae of COVID-19

Y Xie, T Choi, Z Al-Aly - MedRxiv, 2022 - medrxiv.org
Long Covid–the disease encompassing the post-acute sequelae of SARS-CoV-2 (PASC)—
affects millions of people around the world. Prevention of PASC is an urgent public health …

[HTML][HTML] Effect of oral nirmatrelvir on long COVID symptoms: 4 cases and rationale for systematic studies

MJ Peluso, K Anglin, MS Durstenfeld… - Pathogens and …, 2022 - ncbi.nlm.nih.gov
Background: Efforts to understand the impact of SARS-CoV-2 variants, vaccine status, and
treatment on the development and persistence of Long COVID have intensified. Methods …

Nirmatrelvir and ritonavir for inpatients with severe or critical COVID-19 beyond five days of symptom onset: a propensity score-matched, multicenter, retrospective …

H Zhang, X Tan, Z Zhang, C Wang, H Shi, Y Li… - BMC Infectious …, 2024 - Springer
Background There is an urgent need for therapeutic strategies for inpatients with severe or
critical COVID-19. The evaluation of the clinical benefits of nirmatrelvir and ritonavir (Nmr/r) …