We have recently identified apelin as a novel adipokine up‐regulated by insulin and obesity.
Since obesity and insulin resistance are associated with chronically elevated levels of both …

The results presented herein demonstrate that apelin is expressed and secreted by both
human and mouse adipocytes. Apelin mRNA levels in isolated adipocytes are close to other …

Apelin, an adipocyte-secreted factor upregulated by insulin, is increased in adipose tissue
(AT) and plasma with obesity. Apelin was recently identified as a new player in the control of …

Objective: Apelin is an adipokine which plays a role in the regulation of glucose
homeostasis and may contribute to the link between increased adipose tissue mass and …

Objective Apelin is a novel adipokine acting on APJ receptor, regulated by insulin and tumor
necrosis factor-α (TNF-α) in adipose tissue (AT). Plasma apelin levels are increased in …

Apelin is an adipokine secreted by adipocytes. Co-expression of apelin and apelin receptor
(APJ) in adipocytes implies the autocrine regulations of apelin on adipocyte functions …

Adipose tissue (AT) secretes several adipokines that influence insulin sensitivity and
potentially link obesity to insulin resistance. Apelin, a peptide present in different tissues, is …

The release of free fatty acids (FFAs) from adipocytes (ie lipolysis) is increased in obesity
and is a contributory factor to the development of insulin resistance. A recently identified …

Brown adipose tissue expends energy in the form of heat via the mitochondrial uncoupling
protein UCP1. Recent studies showed that brown adipose tissue is present in adult humans …

Background The physiological role of apelin in obesity and diabetes remains unclear.
Although apelin has been studied in persons with different conditions, no studies have yet …