Red blood cells (RBC) have been considered almost exclusively as a transporter of
metabolic gases and nutrients for the tissues. It is an accepted dogma that RBCs take up …

The synthesis of nitric oxide (NO) in the circulation has been attributed exclusively to the
vascular endothelium. Red blood cells (RBCs) have been demonstrated to carry a …

Reduction of nitrite (NO2−) provides a major source of nitric oxide (NO) in the circulation,
especially in hypoxemic conditions. Our previous studies suggest that xanthine …

Background & aims Nitric oxide bioactivity (NO) from endothelial NO synthase (eNOS)
importantly contributes to the maintenance of vascular homeostasis, and reduced eNOS …

Background: Current paradigms suggest that nitric oxide (NO) produced by endothelial cells
(ECs) through endothelial nitric oxide synthase (eNOS) in the vessel wall is the primary …

Nitric oxide (NO), one of the most important vascular signaling molecules, is primarily
produced by endothelial NO synthase (eNOS). eNOS is tightly regulated by its substrate l …

Nitric oxide (NO) is a signaling molecule of major importance modulating not only the
function of the vascular wall but also that of blood cells, such as platelets and leukocytes …

Since the identification of the elusive endothelium-derived relaxing factor as nitric oxide
(NO), much attention has been devoted to understanding its physiological effects. NO is a …

A nitric oxide synthase (NOS)–like activity has been demonstrated in human red blood cells
(RBCs), but doubts about its functional significance, isoform identity and disease relevance …

Red blood cells (RBCs) were shown to transport and release nitric oxide (NO) bioactivity
and carry an endothelial NO synthase (eNOS). However, the pathophysiological …