Purpose To assess efficacy and safety of chloroquine (CQ)/hydroxychloroquine (HCQ) for
treatment or prophylaxis of COVID-19 in adult humans. Materials and methods MEDLINE …

Objectives The emergence of SARS‐CoV‐2 has presented clinicians with a difficult
therapeutic dilemma. With supportive care as the current mainstay of treatment, the fatality …

Background Hydroxychloroquine (HCQ) is an anti-malarial and immunomodulatory drug
considered a potential candidate for drug repurposing in COVID-19 due to their in vitro …

In December 2019, the novel coronavirus disease pandemic (COVID-19) that began in
China had infected so far more than 109,217,366 million individuals worldwide and …

Background On the 11 March 2020, the World Health Organization (WHO) declared that
COVID-19 was a pandemic. To date, there are no medical treatments for COVID-19 with …

Abstract The coronavirus disease 19 (COVID-19) pandemic has caused significant morbidity
and mortality worldwide and an effective treatment is needed. Chloroquine (CQ) and …

Substantial COVID-19 research investment has been allocated to randomized clinical trials
(RCTs) on hydroxychloroquine/chloroquine, which currently face recruitment challenges or …

An update is available for this article. Background: Hydroxychloroquine and chloroquine
have antiviral effects in vitro against severe acute respiratory syndrome coronavirus 2 …

Objectives Clinical studies of chloroquine (CQ) and hydroxychloroquine (HCQ) in COVID-19
disease reported conflicting results. We sought to systematically evaluate the effect of CQ …

Background There is no effective therapy for COVID-19. Hydroxychloroquine (HCQ) and
chloroquine (CQ) have been used for its treatment but their safety and efficacy remain …