The aggregation of alpha-synuclein (α-Syn) plays a critical role in the development of
Parkinson's disease (PD) and other synucleinopathies. α-Syn, which is encoded by the …

Alpha-synuclein (α-syn) is localized in cellular organelles of most neurons, but many of its
physiological functions are only partially understood. α-syn accumulation is associated with …

Abstract Alpha-synuclein (α-syn) is an abundant neuronal protein whose physiological
function, even if still not completely understood, has been consistently related to synaptic …

Abnormal biology of α-synuclein (α-Syn) is directly implicated in the pathogenesis of
Parkinson's disease and other α-synucleinopathies. Herein, we demonstrate that C …

Abstract α-Synuclein (α-Syn) has been extensively studied for its structural and biophysical
properties owing to its pathophysiological role in Parkinson's disease (PD). Lewy bodies …

Over the last two decades, many experimental and clinical studies have provided solid
evidence that alpha-synuclein (α-syn), a small, natively unfolded protein, is closely related to …

A better understanding of the molecular and cellular determinants that influence the
pathology of Parkinson's disease (PD) is essential for developing effective diagnostic …

Parkinson's disease (PD) is a pathological condition characterized by the aggregation and
the resultant presence of intraneuronal inclusions termed Lewy bodies (LBs) and Lewy …

Highlights•Recent publications describe native αSyn assembly forms (tetramers/multimers).•
Physiological αSyn tetramers/multimers are in an equilibrium with monomers.•The multimer …

The aggregation of alpha synuclein (α‐syn) is a neuropathological feature that defines a
spectrum of disorders collectively termed synucleinopathies, and of these, Parkinson's …