The objective of my research was to investigate the rare and very-rare genetic factors
influencing female reproductive ageing in humans using large-scale population exome …

In recent years, common genetic variants have been identified by genome-wide association
studies (GWASs) that have led to the detection of 44 genetic loci associated with …

Premature ovarian insufficiency (POI) affects 1% of women and is a leading cause of
infertility. It is often considered to be a monogenic disorder, with pathogenic variants in~ 100 …

Premature ovarian insufficiency (POI) affects 1% of women and is a leading cause of
infertility. It is often considered to be a monogenic disorder, with pathogenic variants in∼ …

Menopause timing is highly variable, having a direct effect on reproductive lifespan, fertility
and health outcomes in later life. Endocrine and imaging tests only record changes in …

Women become infertile approximately 10 years before menopause, and as more women
delay childbirth into their 30s, the number of women who experience infertility is likely to …

Dissecting the genetics of ovarian ageing | Nature Reviews Genetics Skip to main content
Thank you for visiting nature.com. You are using a browser version with limited support for …

Study question What is the penetrance of variants in previously reported genes for
premature ovarian insufficiency (POI) in the general population? Summary answer …

Premature ovarian insufficiency (POI) affects 1% of women and is a leading cause of
infertility. It is often considered to be a monogenic disorder, with pathogenic variants in~ 100 …

Premature ovarian failure (POF), also known as premature menopause, is defined as at
least six months of amenorrhea before the age of 40 with elevated gonadotrophins and …