A signature of ionizing radiation exposure is the induction of DNA clustered damaged sites,
defined as two or more lesions within one to two helical turns of DNA by passage of a single …

Clustered DNA lesions, also called Multiply Damaged Sites, is the hallmark of ionizing
radiation. It is defined as the combination of two or more lesions, comprising strand breaks …

A clustered DNA lesion, also known as a multiply damaged site, is defined as≥ 2 damages
in the DNA within 1–2 helical turns. Only ionizing radiation and certain chemicals introduce …

The accumulated evidence in the literature indicates that a cluster of two or more lesions
within one or two helical turns of the DNA is more challenging to repair than individual …

In addition to double‐and single‐strand DNA breaks and isolated base modifications,
ionizing radiation induces clustered DNA damage, which contains two or more lesions …

Cells manage to survive, thrive, and divide with high accuracy despite the constant threat of
DNA damage. Cells have evolved with several systems that efficiently repair spontaneous …

Abstract Hada, M. and Sutherland, BM Spectrum of Complex DNA Damages Depends on
the Incident Radiation. Radiat. Res. 165, 223–230 (2006). Ionizing radiation induces …

Clustered DNA damages—two or more closely spaced damages (strand breaks, abasic
sites, or oxidized bases) on opposing strands—are suspects as critical lesions producing …

Several proteins involved in DNA repair and DNA damage signaling have been shown to
produce discrete foci in response to ionizing radiation. These foci are believed to co-localize …

Ionising radiation induces clustered DNA damage sites which pose a severe challenge to
the cell's repair machinery, particularly base excision repair. To date, most studies have …