Gastrointestinal (GI) cancers are a major cause of cancer-related deaths. During the last two
decades, several studies have shown amplification and overexpression of Aurora kinase A …

BACKGROUND Upper gastrointestinal adenocarcinomas are a common cause of cancer‐
related deaths. In this study, the authors investigated the prevalence and biological …

Compounds that affect enzymatic function of kinases are valuable for the understanding of
the complex biochemical processes in cells. Aurora kinases (AURKs) play a key role in the …

Aurora kinase A (AURKA) belongs to the family of serine/threonine kinases, whose
activation is necessary for cell division processes via regulation of mitosis. AURKA shows …

Aurora kinases (AURKs) are serine/threonine protein kinases that play a critical role during
cell proliferation. Three isoforms of AURKs reported in mammals include AURKA, AURKB …

Background & Aims Chronic inflammation contributes to the pathogenesis of gastric
tumorigenesis. The aurora kinase A (AURKA) gene is frequently amplified and …

Esophageal adenocarcinomas are poorly responsive to chemotherapeutics. This study
aimed to determine the levels of Aurora kinase A (AURKA) and the therapeutic potential of …

Abstract Purpose: Aurora kinase A (AURKA) is overexpressed in several cancer types,
making it an attractive druggable target in clinical trials. In this study, we investigated the role …

Aurora kinase B (AURKB) is a mitotic serine/threonine protein kinase that belongs to the
aurora kinase family along with aurora kinase A (AURKA) and aurora kinase C (AURKC) …

Recent advances in high-throughput sequencing technologies and data science have
facilitated the development of precision medicine to treat cancer patients. Synthetic lethality …