[HTML][HTML] Aging and age‐related diseases: from mechanisms to therapeutic strategies

Z Li, Z Zhang, Y Ren, Y Wang, J Fang, H Yue, S Ma… - Biogerontology, 2021 - Springer
Aging is a physiological process mediated by numerous biological and genetic pathways,
which are directly linked to lifespan and are a driving force for all age-related diseases …

Epigenetic mechanisms of longevity and aging

P Sen, PP Shah, R Nativio, SL Berger - Cell, 2016 - cell.com
Aging is an inevitable outcome of life, characterized by progressive decline in tissue and
organ function and increased risk of mortality. Accumulating evidence links aging to genetic …

Transcriptional signatures of aging

R Stegeman, VM Weake - Journal of molecular biology, 2017 - Elsevier
Genome-wide studies of aging have identified subsets of genes that show age-related
changes in expression. Although the types of genes that are age regulated vary among …

[HTML][HTML] Synchronized age-related gene expression changes across multiple tissues in human and the link to complex diseases

J Yang, T Huang, F Petralia, Q Long, B Zhang… - Scientific reports, 2015 - nature.com
Aging is one of the most important biological processes and is a known risk factor for many
age-related diseases in human. Studying age-related transcriptomic changes in tissues …

Epigenetics and oxidative stress in aging

A Guillaumet-Adkins, Y Yañez… - Oxidative medicine …, 2017 - Wiley Online Library
Aging is a multifactorial process characterized by the progressive loss of physiological
functions, leading to an increased vulnerability to age‐associated diseases and finally to …

Key signaling pathways in aging and potential interventions for healthy aging

M Yu, H Zhang, B Wang, Y Zhang, X Zheng, B Shao… - Cells, 2021 - mdpi.com
Aging is a fundamental biological process accompanied by a general decline in tissue
function. Indeed, as the lifespan increases, age-related dysfunction, such as cognitive …

[HTML][HTML] Stress, epigenetics, and aging: unraveling the intricate crosstalk

Z Wu, J Qu, W Zhang, GH Liu - Molecular Cell, 2024 - cell.com
Aging, as a complex process involving multiple cellular and molecular pathways, is known to
be exacerbated by various stresses. Because responses to these stresses, such as oxidative …

[HTML][HTML] The hallmarks of aging

C López-Otín, MA Blasco, L Partridge, M Serrano… - Cell, 2013 - cell.com
Aging is characterized by a progressive loss of physiological integrity, leading to impaired
function and increased vulnerability to death. This deterioration is the primary risk factor for …

Aging: somatic mutations, epigenetic drift and gene dosage imbalance

RA Veitia, DR Govindaraju, S Bottani, JA Birchler - Trends in Cell Biology, 2017 - cell.com
Aging involves a progressive decline of metabolic function and an increased incidence of
late-onset degenerative disorders and cancer. To a large extent, these processes are …

Aging epigenetics: causes and consequences

C Huidobro, AF Fernandez, MF Fraga - Molecular Aspects of Medicine, 2013 - Elsevier
Growth and development of higher organisms are regulated by the orchestrated change of
epigenetic marks over time. In addition, there is also an epigenetic variation without any …