Mammalian aging can be delayed with genetic, dietary and pharmacologic approaches.
Given that the elderly population is dramatically increasing and that aging is the greatest risk …

Human aging is associated with a decline of physical and cognitive function and high
susceptibility to chronic diseases, which is influenced by genetics, epigenetics …

Disease epidemiology during ageing shows a transition from cancer to degenerative chronic
disorders as dominant contributors to mortality in the old. Nevertheless, it has remained …

Instead of considering aging in terms of discrete hallmarks, we suggest that it operates in
four layers, each at a different biological scale. Malfunctions within each layer—and …

Ageing is the main risk factor for human neurological disorders. Among the diverse
molecular pathways that govern ageing, epigenetics can guide age-associated decline in …

Ageing is characterized by a progressive accumulation of molecular damage in nucleic
acids, proteins and lipids. The inefficiency and failure of maintenance, repair and turnover …

Aging is an inevitable process of life. Defined by progressive physiological and functional
loss of tissues and organs, aging increases the risk of mortality for the organism. The aging …

Simone Ecker and Stephan Beck www. aging-us. com AGING 2019, Vol. 11, No. 2 www.
aging-us. com 833 AGING advantage over the multi-tissue clock which does not work well in …

Cellular senescence is a state of permanent cell cycle arrest accompanied by unique
secretory actions, which influences tissue formation, tumor suppression and aging in vivo …

Cellular senescence as the state of permanent inhibition of cell proliferation is a tumour-
suppressive mechanism. However, due to the associated secretory phenotype senescence …