Nonmotor manifestations in Parkinson's disease (PD) encompass a range of clinical
features, including neuropsychiatric problems, autonomic dysfunction, sleep disorders …

In the mid‐1980s, the treatment of Parkinson's disease was quite exclusively centered on
dopatherapy and was focusing on dopamine systems and motor symptoms. A few dopamine …

The neurodegenerative process is well established in Parkinson patients presenting to a
physician with early motor signs. There is increasing evidence that a variety of nonmotor …

Cognitive impairment in Parkinson's disease (PD) is a frequent complication, with significant
interindividual variability in clinical symptoms, severity, timing, and neural substrates. Recent …

Many therapeutic interventions are available for the management of Parkinson's disease
including drugs, surgical interventions and physical treatments. They are not equally …

This article reviews and summarizes 200 years of Parkinson's disease. It comprises a
relevant history of Dr. James Parkinson's himself and what he described accurately and …

The purpose of this systematic review is to summarize studies that describe the course of
Parkinson's disease (PD) and to identify factors that predict change in motor impairment …

Despite all recent advances in symptomatic therapy Parkinson's disease (PD) continues to
be a relentlessly progressive neurodegenerative disorder. Therefore therapies that will slow …

James Parkinson has been credited for almost 200 years with establishing the major clinical
features of Parkinson's disease (PD), and we remain in awe of his observational and …

Abstract Background and Purpose This update of the treatment guidelines was
commissioned by the European Academy of Neurology and the European section of the …