The immune system shows a decline in responsiveness to antigens both with aging, as well
as in the presence of tumors. The malfunction of the immune system with age can be …

Dendritic cells (DCs) play a critical role in linking innate and adaptive immunity. A role of
DCs in immunosenescence and chronic inflammation associated with aging has not been …

Effective cancer immunotherapy depends on the body's ability to generate tumor antigen-
presenting cells and tumor-reactive effector lymphocytes. As the most potent antigen …

The immune system has evolved to mount immune responses against foreign pathogens
and to remain silent against self-antigens. A balance between immunity and tolerance is …

Dendritic cells (DC) are known as the most efficient antigen-presenting cell type to activate T
cells and are key modulators of the immune response. Due to their central role in …

Aging is associated with a progressive decline in T cell function, chronic inflammation,
hyperimmunoglobulinemia, autoimmunity, poor response to vaccines, and increased …

Aging is a paradox of reduced immunity and chronic inflammation. Dendritic cells are central
orchestrators of the immune response with a key role in the generation of immunity and …

Immunosenescence, the progressive decline in immune function that develops with age,
results from cumulative alterations in critical B-and T-cell subpopulations. Decreases in …

Dendritic cells are central to the generation of both immunity and tolerance. This review
focuses on the alterations in the functions of dendritic cells in aged and its consequences on …

Aging is characterized by the gradual decline in immune function. Dendritic cells (DC) are
potent antigen-presenting cells that regulate the balance between immunity and tolerance …