[HTML][HTML] Panax notoginseng saponins alleviates advanced glycation end product-induced apoptosis by upregulating SIRT1 and antioxidant expression levels in …

Y Bo, Z Jian, S Zhi-Jun, W Quing… - Experimental and …, 2020 - spandidos-publications.com
The present study examined whether Panax notoginseng saponins (PNS) alleviated
advanced glycation end product (AGE)-induced apoptosis in human umbilical vein …

[HTML][HTML] Ginsenoside Rg1 ameliorates apoptosis, senescence and oxidative stress in ox‑LDL‑induced vascular endothelial cells via the AMPK/SIRT3/p53 signaling …

TJ Lyu, ZX Zhang, J Chen… - Experimental and …, 2022 - spandidos-publications.com
Coronary heart disease (CHD) mainly refers to coronary atherosclerotic heart disease and
its pathogenesis is complex. Ginsenoside Rg1 (Rg1) has a wide range of pharmacological …

Panax notoginseng saponins attenuate cardiomyocyte apoptosis through mitochondrial pathway in natural aging rats

Z Zhou, J Wang, Y Song, Y He, C Zhang… - Phytotherapy …, 2018 - Wiley Online Library
Panax notoginseng saponins (PNS) have been widely used in the cardiovascular system for
the treatment of cardiovascular diseases and stroke in China. In this study, we investigated …

The protective effect of Smilax glabra extract on advanced glycation end products-induced endothelial dysfunction in HUVECs via RAGE-ERK1/2-NF-κB pathway

H Sang, J Gu, J Yuan, M Zhang, X Jia, L Feng - Journal of …, 2014 - Elsevier
Abstract Ethnopharmacological relevance Smilax glabra Roxb.(SGR) is a traditional
Chinese herb that has been used in folk for the treatment of diabetic vascular complications …

[HTML][HTML] Saponins of Panax japonicus ameliorates cardiac aging phenotype in aging rats by enhancing basal autophagy through AMPK/mTOR/ULK1 pathway

H Huang, T Wang, L Wang, Y Huang, W Li, Y Hu… - Experimental …, 2023 - Elsevier
Heart disease is a significant health concern for elderly individuals, with heart aging being
the primary cause. Recent studies have shown that autophagy can play a protective role in …

Grape seed procyanidin B2 inhibits advanced glycation end product‐induced endothelial cell apoptosis through regulating GSK3β phosphorylation

B Li, X Li, H Gao, J Zhang, Q Cai… - Cell Biology …, 2011 - Wiley Online Library
To investigate the effects of GSPB2 (grape seed procyanidin B2) on the apoptosis of
HUVECs (human umbilical endothelial cells) induced by AGEs (advanced glycation end …

Tetrahydroxystilbene glucoside alleviates angiotensin II induced HUVEC senescence via SIRT1

W Fan, Y Guo, S Cao, S Cao, Y Xie… - Canadian journal of …, 2021 - cdnsciencepub.com
Tetrahydroxystilbene glucoside (TSG), an active ingredient of Polygonum multiflorum, has
been known for certain anti-aging effects. In this study, the possible protective mechanism of …

Protection of kinsenoside against AGEs-induced endothelial dysfunction in human umbilical vein endothelial cells

Q Liu, AM Qiao, LT Yi, ZL Liu, SM Sheng - Life Sciences, 2016 - Elsevier
Aims Kinsenoside is the major ingredient of Anoectochilus roxburghii which is a traditional
Chinese herb using for the treatment of diabetes. The present study investigated the safety …

Effect of saponins extracted from Panax japonicus on inhibiting cardiomyocyte apoptosis by AMPK/Sirt1/NF-κB signaling pathway in aging rats

YN Song, D Yuan, CC Zhang, LP Wang… - Zhongguo Zhong yao …, 2017 - europepmc.org
To investigate the effects of saponins extracted from Panax japonicus (SPJ) on
cardiomyocyte apoptosis in natural aging rats and explore its underlying mechanisms. SD …

Andrographis paniculata Ethanol Extract Alleviates High Glucose-induced Senescence of Human Umbilical Vein Endothelial Cells via the Regulation of mTOR and …

NG Khatimah, W Arozal, AJ Barinda… - The Indonesian …, 2024 - inabj.org
BACKGROUND: Chronic exposure of high glucose (HG) in endothelial cell induces
senescence which may contribute to the development and progression of age-related …