Genetic and structural basis for recognition of SARS-CoV-2 spike protein by a two-antibody cocktail
The SARS-CoV-2 pandemic has led to an urgent need to understand the molecular basis for
immune recognition of SARS-CoV-2 spike (S) glycoprotein antigenic sites. To define the …
immune recognition of SARS-CoV-2 spike (S) glycoprotein antigenic sites. To define the …
An antibody that neutralizes SARS-CoV-1 and SARS-CoV-2 by binding to a conserved spike epitope outside the receptor binding motif
The rapid evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),
such as the Omicron variants that are highly transmissible and immune evasive …
such as the Omicron variants that are highly transmissible and immune evasive …
SARS-CoV-2 infection induces robust, neutralizing antibody responses that are stable for at least three months
SARS-CoV-2 has caused a global pandemic with millions infected and numerous fatalities.
Questions regarding the robustness, functionality and longevity of the antibody response to …
Questions regarding the robustness, functionality and longevity of the antibody response to …
A proof of concept for neutralizing antibody-guided vaccine design against SARS-CoV-2
L Zhang, L Cao, XS Gao, BY Zheng… - National Science …, 2021 - academic.oup.com
Mutations and transient conformational movements of the receptor binding domain (RBD)
that make neutralizing epitopes momentarily unavailable present immune escape routes for …
that make neutralizing epitopes momentarily unavailable present immune escape routes for …
Neutralization mechanism of a human antibody with pan-coronavirus reactivity including SARS-CoV-2
Frequent outbreaks of coronaviruses underscore the need for antivirals and vaccines that
can counter a broad range of coronavirus types. We isolated a human antibody named 76E1 …
can counter a broad range of coronavirus types. We isolated a human antibody named 76E1 …
[HTML][HTML] Development of potency, breadth and resilience to viral escape mutations in SARS-CoV-2 neutralizing antibodies
Antibodies elicited in response to infection undergo somatic mutation in germinal centers
that can result in higher affinity for the cognate antigen. To determine the effects of somatic …
that can result in higher affinity for the cognate antigen. To determine the effects of somatic …
The functions of SARS-CoV-2 neutralizing and infection-enhancing antibodies in vitro and in mice and nonhuman primates
Summary SARS-CoV-2 neutralizing antibodies (NAbs) protect against COVID-19, making
them a focus of vaccine design. A safety concern regarding SARS-CoV-2 antibodies is …
them a focus of vaccine design. A safety concern regarding SARS-CoV-2 antibodies is …
A SARS-CoV-2 antibody broadly neutralizes SARS-related coronaviruses and variants by coordinated recognition of a virus-vulnerable site
T Onodera, S Kita, Y Adachi, S Moriyama, A Sato… - Immunity, 2021 - cell.com
Potent neutralizing SARS-CoV-2 antibodies often target the spike protein receptor-binding
site (RBS), but the variability of RBS epitopes hampers broad neutralization of multiple …
site (RBS), but the variability of RBS epitopes hampers broad neutralization of multiple …
Discovery and multimerization of cross-reactive single-domain antibodies against SARS-like viruses to enhance potency and address emerging SARS-CoV-2 variants
SA Hollingsworth, CL Noland, K Vroom, A Saha… - Scientific Reports, 2023 - nature.com
Coronaviruses have been the causative agent of three epidemics and pandemics in the past
two decades, including the ongoing COVID-19 pandemic. A broadly-neutralizing …
two decades, including the ongoing COVID-19 pandemic. A broadly-neutralizing …
[HTML][HTML] Bispecific IgG neutralizes SARS-CoV-2 variants and prevents escape in mice
Neutralizing antibodies that target the receptor-binding domain (RBD) of the SARS-CoV-2
spike protein are among the most promising approaches against COVID-19,. A bispecific …
spike protein are among the most promising approaches against COVID-19,. A bispecific …