Fighting COVID-19 exhausts T cells
C Moon - Nature Reviews Immunology, 2020 - nature.com
Acute respiratory distress syndrome (ARDS) and robust cytokine storm are the hallmark of
severe COVID-19 cases. Using single-cell RNA sequencing of bronchoalveolar lavage fluid …
severe COVID-19 cases. Using single-cell RNA sequencing of bronchoalveolar lavage fluid …
In the eye of the COVID-19 cytokine storm
N Vaninov - Nature Reviews Immunology, 2020 - nature.com
Acute respiratory distress syndrome (ARDS) and robust cytokine storm are the hallmark of
severe COVID-19 cases. Using single-cell RNA sequencing of bronchoalveolar lavage fluid …
severe COVID-19 cases. Using single-cell RNA sequencing of bronchoalveolar lavage fluid …
[PDF][PDF] Cell-type-specific immune dysregulation in severely ill COVID-19 patients
Recent studies have demonstrated immunologic dysfunction in severely ill coronavirus
disease 2019 (COVID-19) patients. We use single-cell RNA sequencing (scRNA-seq) to …
disease 2019 (COVID-19) patients. We use single-cell RNA sequencing (scRNA-seq) to …
[HTML][HTML] COVID-19-induced ARDS is associated with decreased frequency of activated memory/effector T cells expressing CD11a++
M Anft, K Paniskaki, A Blazquez-Navarro, A Doevelaar… - Molecular Therapy, 2020 - cell.com
Preventing the progression to acute respiratory distress syndrome (ARDS) in COVID-19 is
an unsolved challenge. The involvement of T cell immunity in this exacerbation remains …
an unsolved challenge. The involvement of T cell immunity in this exacerbation remains …
Pathogenic T-cells and inflammatory monocytes incite inflammatory storms in severe COVID-19 patients
Y Zhou, B Fu, X Zheng, D Wang, C Zhao… - National Science …, 2020 - academic.oup.com
Pathogenic human coronavirus infections, such as severe acute respiratory syndrome CoV
(SARS-CoV) and Middle East respiratory syndrome CoV (MERS-CoV), cause high morbidity …
(SARS-CoV) and Middle East respiratory syndrome CoV (MERS-CoV), cause high morbidity …
[HTML][HTML] The differential immune responses to COVID-19 in peripheral and lung revealed by single-cell RNA sequencing
Understanding the mechanism that leads to immune dysfunction in severe coronavirus
disease 2019 (COVID-19) is crucial for the development of effective treatment. Here, using …
disease 2019 (COVID-19) is crucial for the development of effective treatment. Here, using …
[PDF][PDF] Longitudinal profiling of respiratory and systemic immune responses reveals myeloid cell-driven lung inflammation in severe COVID-19
Immune response dynamics in coronavirus disease 2019 (COVID-19) and their severe
manifestations have largely been studied in circulation. Here, we examined the relationship …
manifestations have largely been studied in circulation. Here, we examined the relationship …
[HTML][HTML] A glimpse into the eye of the COVID-19 cytokine storm
K Kuppalli, AL Rasmussen - EBioMedicine, 2020 - thelancet.com
The pathogenesis of pandemic coronavirus disease-2019 (COVID-19) caused by severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) likely depends heavily on …
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) likely depends heavily on …
[HTML][HTML] Severe COVID-19 is associated with deep and sustained multifaceted cellular immunosuppression
R Jeannet, T Daix, R Formento, J Feuillard… - Intensive care …, 2020 - Springer
Dear Editor, SARS-CoV-2 infection is associated with marked lymphopenia that correlates
with morbidity and mortality [1, 2]. Here, we present the first report on serial …
with morbidity and mortality [1, 2]. Here, we present the first report on serial …
[HTML][HTML] Single-cell multi-omics analysis of the immune response in COVID-19
Abstract Analysis of human blood immune cells provides insights into the coordinated
response to viral infections such as severe acute respiratory syndrome coronavirus 2, which …
response to viral infections such as severe acute respiratory syndrome coronavirus 2, which …