Automatic filtering and substantiation of drug safety signals
A Bauer-Mehren, EM van Mullingen… - PLoS computational …, 2012 - journals.plos.org
Drug safety issues pose serious health threats to the population and constitute a major
cause of mortality worldwide. Due to the prominent implications to both public health and the …
cause of mortality worldwide. Due to the prominent implications to both public health and the …
Linking biochemical pathways and networks to adverse drug reactions
There is growing interest in investigating the biochemical pathways involved in cellular
responses to drugs. Here we propose new methods to explore the relationships between …
responses to drugs. Here we propose new methods to explore the relationships between …
Advancing drug safety science by integrating molecular knowledge with post‐marketing adverse event reports
TG Soldatos, S Kim, S Schmidt… - CPT …, 2022 - Wiley Online Library
Promising drug development efforts may frequently fail due to unintended adverse reactions.
Several methods have been developed to analyze such data, aiming to improve …
Several methods have been developed to analyze such data, aiming to improve …
Systems biology approaches for identifying adverse drug reactions and elucidating their underlying biological mechanisms
Small molecules are indispensable to modern medical therapy. However, their use may lead
to unintended, negative medical outcomes commonly referred to as adverse drug reactions …
to unintended, negative medical outcomes commonly referred to as adverse drug reactions …
Improving drug safety: From adverse drug reaction knowledge discovery to clinical implementation
Adverse drug reactions (ADRs) are a major public health concern, causing over 100,000
fatalities in the United States every year with an annual cost of $136 billion. Early detection …
fatalities in the United States every year with an annual cost of $136 billion. Early detection …
A structure-based approach for mapping adverse drug reactions to the perturbation of underlying biological pathways
I Wallach, N Jaitly, R Lilien - PloS one, 2010 - journals.plos.org
Adverse drug reactions (ADR), also known as side-effects, are complex undesired
physiologic phenomena observed secondary to the administration of pharmaceuticals …
physiologic phenomena observed secondary to the administration of pharmaceuticals …
Needs for an expanded ontology‐based classification of adverse drug reactions and related mechanisms
The growing significance of bioinformatics and systems biology in drug safety research
requires a system of adverse‐event classification that goes beyond a simple vocabulary …
requires a system of adverse‐event classification that goes beyond a simple vocabulary …
Pharmacological mechanism‐based drug safety assessment and prediction
DR Abernethy, J Woodcock… - Clinical Pharmacology & …, 2011 - Wiley Online Library
Advances in cheminformatics, bioinformatics, and pharmacology in the context of biological
systems are now at a point that these tools can be applied to mechanism‐based drug safety …
systems are now at a point that these tools can be applied to mechanism‐based drug safety …
Machine learning guided association of adverse drug reactions with in vitro target-based pharmacology
Abstract Background Adverse drug reactions (ADRs) are one of the leading causes of
morbidity and mortality in health care. Understanding which drug targets are linked to ADRs …
morbidity and mortality in health care. Understanding which drug targets are linked to ADRs …
Systems approaches in risk assessment
Adverse drug events (ADEs) remain a universal problem in drug development, regulatory
review, and clinical practice with a substantial financial burden on the global health‐care …
review, and clinical practice with a substantial financial burden on the global health‐care …