mRNA-1273 vaccine induces neutralizing antibodies against spike mutants from global SARS-CoV-2 variants

K Wu, AP Werner, JI Moliva, M Koch, A Choi… - BioRxiv, 2021 - biorxiv.org
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the causative infection of
a global pandemic that has led to more than 2 million deaths worldwide. The Moderna …

Structural basis for potent antibody neutralization of SARS-CoV-2 variants including B. 1.1. 529

T Zhou, L Wang, J Misasi, A Pegu, Y Zhang, DR Harris… - Science, 2022 - science.org
The rapid spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) B.
1.1. 529 (Omicron) variant and its resistance to neutralization by vaccinee and convalescent …

High genetic barrier to SARS-CoV-2 polyclonal neutralizing antibody escape

F Schmidt, Y Weisblum, M Rutkowska, D Poston… - Nature, 2021 - nature.com
The number and variability of the neutralizing epitopes targeted by polyclonal antibodies in
individuals who are SARS-CoV-2 convalescent and vaccinated are key determinants of …

Neutralizing and protective human monoclonal antibodies recognizing the N-terminal domain of the SARS-CoV-2 spike protein

N Suryadevara, S Shrihari, P Gilchuk, LA VanBlargan… - Cell, 2021 - cell.com
Most human monoclonal antibodies (mAbs) neutralizing SARS-CoV-2 recognize the spike
(S) protein receptor-binding domain and block virus interactions with the cellular receptor …

Neutralization of SARS-CoV-2 variants of concern harboring Q677H

C Zeng, JP Evans, JN Faraone, P Qu, YM Zheng, L Saif… - MBio, 2021 - Am Soc Microbiol
The sensitivity of SARS-CoV-2 variants of concern (VOCs) to neutralizing antibodies has
largely been studied in the context of key receptor binding domain (RBD) mutations …

A SARS-CoV-2 variant elicits an antibody response with a shifted immunodominance hierarchy

AJ Greaney, TN Starr, RT Eguia, AN Loes… - PLoS …, 2022 - journals.plos.org
Many SARS-CoV-2 variants have mutations at key sites targeted by antibodies. However, it
is unknown if antibodies elicited by infection with these variants target the same or different …

Crucial mutations of spike protein on SARS-CoV-2 evolved to variant strains escaping neutralization of convalescent plasmas and RBD-specific monoclonal …

C Ding, J He, X Zhang, C Jiang, Y Sun… - Frontiers in …, 2021 - frontiersin.org
Small number of SARS-CoV-2 epidemic lineages did not efficiently exhibit a neutralization
profile, while single amino acid mutation in the spike protein has not been confirmed in …

Key substitutions in the spike protein of SARS-CoV-2 variants can predict resistance to monoclonal antibodies, but other substitutions can modify the effects

S Lusvarghi, W Wang, R Herrup… - Journal of …, 2022 - Am Soc Microbiol
Mutations in the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) variants can compromise the effectiveness of therapeutic antibodies. Most clinical …

[HTML][HTML] Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity

WF Garcia-Beltran, EC Lam, KS Denis, AD Nitido… - Cell, 2021 - cell.com
Vaccination elicits immune responses capable of potently neutralizing SARS-CoV-2.
However, ongoing surveillance has revealed the emergence of variants harboring mutations …

Neutralization of SARS-CoV-2 variants by mRNA and adenoviral vector vaccine-elicited antibodies

T Tada, H Zhou, MI Samanovic, BM Dcosta… - Frontiers in …, 2022 - frontiersin.org
The increasing prevalence of SARS-CoV-2 variants has raised concerns regarding possible
decreases in vaccine effectiveness. Here, neutralizing antibody titers elicited by mRNA …