The genetic risk for COVID-19 severity is associated with defective immune responses
Y Kuijpers, X Chu, M Jaeger, SJ Moorlag… - Frontiers in …, 2022 - frontiersin.org
Recent genome-wide association studies (GWASs) of COVID-19 patients of European
ancestry have identified genetic loci significantly associated with disease severity. Here, we …
ancestry have identified genetic loci significantly associated with disease severity. Here, we …
Deciphering the role of host genetics in susceptibility to severe COVID-19
ME Carter-Timofte, SE Jørgensen, MR Freytag… - Frontiers in …, 2020 - frontiersin.org
Coronavirus disease-19 (COVID-19) describes a set of symptoms that develop following
infection by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Whilst …
infection by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Whilst …
[HTML][HTML] Integrative analyses identify susceptibility genes underlying COVID-19 hospitalization
Despite rapid progress in characterizing the role of host genetics in SARS-Cov-2 infection,
there is limited understanding of genes and pathways that contribute to COVID-19. Here, we …
there is limited understanding of genes and pathways that contribute to COVID-19. Here, we …
Immunogenetic association underlying severe COVID-19
K McCoy, A Peterson, Y Tian, Y Sang - Vaccines, 2020 - mdpi.com
SARS-CoV2 has caused the current pandemic of new coronavirus disease 2019 (COVID-
19) worldwide. Clinical outcomes of COVID-19 illness range broadly from asymptotic and …
19) worldwide. Clinical outcomes of COVID-19 illness range broadly from asymptotic and …
[HTML][HTML] A global effort to define the human genetics of protective immunity to SARS-CoV-2 infection
SARS-CoV-2 infection displays immense inter-individual clinical variability, ranging from
silent infection to lethal disease. The role of human genetics in determining clinical response …
silent infection to lethal disease. The role of human genetics in determining clinical response …
A Phenome-Wide Association Study of genes associated with COVID-19 severity reveals shared genetics with complex diseases in the Million Veteran Program
A Verma, NL Tsao, LO Thomann, YL Ho… - PLoS …, 2022 - journals.plos.org
The study aims to determine the shared genetic architecture between COVID-19 severity
with existing medical conditions using electronic health record (EHR) data. We conducted a …
with existing medical conditions using electronic health record (EHR) data. We conducted a …
An explainable model of host genetic interactions linked to COVID-19 severity
A Onoja, N Picchiotti, C Fallerini, M Baldassarri… - Communications …, 2022 - nature.com
We employed a multifaceted computational strategy to identify the genetic factors
contributing to increased risk of severe COVID-19 infection from a Whole Exome …
contributing to increased risk of severe COVID-19 infection from a Whole Exome …
Germline genetic variants of viral entry and innate immunity may influence susceptibility to SARS-CoV-2 infection: toward a polygenic risk score for risk stratification
VK Grolmusz, A Bozsik, J Papp, A Patócs - Frontiers in Immunology, 2021 - frontiersin.org
The ongoing COVID-19 pandemic caused by the novel coronavirus, SARS-CoV-2 has
affected all aspects of human society with a special focus on healthcare. Although older …
affected all aspects of human society with a special focus on healthcare. Although older …
Integrative genomic analyses identify susceptibility genes underlying COVID-19 hospitalization
Despite rapid progress in characterizing the role of host genetics in SARS-Cov-2 infection,
there is limited understanding of genes and pathways that contribute to COVID-19. Here, we …
there is limited understanding of genes and pathways that contribute to COVID-19. Here, we …
Human genetic factors associated with susceptibility to SARS-CoV-2 infection and COVID-19 disease severity
C Anastassopoulou, Z Gkizarioti, GP Patrinos… - Human genomics, 2020 - Springer
Background The emergence of the novel coronavirus in Wuhan, Hubei Province, China, in
December 2019 marked the synchronization of the world to a peculiar clock that is counting …
December 2019 marked the synchronization of the world to a peculiar clock that is counting …