COVID-19 Therapeutics for Nonhospitalized Patients—Updates and Future Directions

KW Chew, PN Malani, RT Gandhi - JAMA, 2023 - jamanetwork.com
Antiviral therapeutics for COVID-19 in nonhospitalized patients prevent progression to
severe illness, hospitalization, and death. Despite their proven benefit, utilization of these …

Effects of potent neutralizing antibodies from convalescent plasma in patients hospitalized for severe SARS-CoV-2 infection

A Gharbharan, CCE Jordans… - Nature …, 2021 - nature.com
In a randomized clinical trial of 86 hospitalized COVID-19 patients comparing standard care
to treatment with 300mL convalescent plasma containing high titers of neutralizing SARS …

COVID-19 convalescent plasma for the treatment of immunocompromised patients: a systematic review and meta-analysis

JW Senefeld, M Franchini, C Mengoli… - JAMA Network …, 2023 - jamanetwork.com
Importance Patients who are immunocompromised have increased risk for morbidity and
mortality associated with coronavirus disease 2019 (COVID-19) because they less …

Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial

P Bégin, J Callum, E Jamula, R Cook, NM Heddle… - Nature medicine, 2021 - nature.com
The efficacy of convalescent plasma for coronavirus disease 2019 (COVID-19) is unclear.
Although most randomized controlled trials have shown negative results, uncontrolled …

Neutralizing COVID-19 convalescent plasma in adults hospitalized with COVID-19: a blinded, randomized, placebo-controlled trial

WH Self, AP Wheeler, TG Stewart, H Schrager… - Chest, 2022 - Elsevier
Background Convalescent plasma has been one of the most common treatments for COVID-
19, but most clinical trial data to date have not supported its efficacy. Research Question Is …

COVID-19 therapeutics for nonhospitalized patients

RT Gandhi, PN Malani, C Del Rio - Jama, 2022 - jamanetwork.com
Substantial progresshas been made in therapeutics for nonhospitalizedpatientswithCOVID-
19, butsupplyofand access to treatment remain limited. This Viewpoint summarizes currently …

Convalescent plasma for COVID-19. A randomized clinical trial

A Gharbharan, CCE Jordans, C Geurtsvankessel… - MEDRxiv, 2020 - medrxiv.org
Structured abstract for full paper Background After recovery from COVID-19, most patients
have anti-SARS-CoV-2 neutralizing antibodies. Their convalescent plasma could be an …

Clinical practice guidelines from the Association for the Advancement of Blood and Biotherapies (AABB): COVID-19 convalescent plasma

LJ Estcourt, CS Cohn, MB Pagano… - Annals of internal …, 2022 - acpjournals.org
Description: Coronavirus disease 2019 convalescent plasma (CCP) has emerged as a
potential treatment of COVID-19. However, meta-analysis data and recommendations are …

[HTML][HTML] Treatment of COVID-19 with convalescent plasma: lessons from past coronavirus outbreaks

DJ Wooding, H Bach - Clinical Microbiology and Infection, 2020 - Elsevier
Background There is currently no treatment known to alter the course of coronavirus disease
2019 (COVID-19). Convalescent plasma has been used to treat a number of infections …

Convalescent plasma treatment of severe COVID-19: a propensity score–matched control study

STH Liu, HM Lin, I Baine, A Wajnberg, JP Gumprecht… - Nature medicine, 2020 - nature.com
Abstract Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), is a new human disease with few effective …