COVID-19: more than a cytokine storm

G Riva, V Nasillo, E Tagliafico, T Trenti, P Comoli… - Critical care, 2020 - Springer
Background In these first months of coronavirus disease-19 (COVID-19) pandemic, a
mainstream pathogenetic hypothesis, likely stemming from early clinico-therapeutic …

The pathogenesis and treatment of theCytokine Storm'in COVID-19

Q Ye, B Wang, J Mao - Journal of infection, 2020 - Elsevier
Cytokine storm is a general term applied to maladaptive cytokine release in response to
infection and other stimuli. The pathogenesis is complex but includes loss of regulatory …

[HTML][HTML] Major alterations to monocyte and dendritic cell subsets lasting more than 6 months after hospitalization for COVID-19

FR Hopkins, M Govender, C Svanberg… - Frontiers in …, 2023 - frontiersin.org
Introduction After more than two years the Coronavirus disease-19 (COVID-19) pandemic
continues to burden healthcare systems and economies worldwide, and it is evident that the …

Tackling the cytokine storm in COVID-19, challenges and hopes

SM Abdin, SM Elgendy, SK Alyammahi, DW Alhamad… - Life Sciences, 2020 - Elsevier
The outbreak of Coronavirus disease 2019 (COVID-19) is the current world health concern,
presenting a public health dilemma with ascending morbidity and mortality rates exceeding …

[HTML][HTML] Mechanistic insights into the immune pathophysiology of COVID-19; an in-depth review

A Shafqat, S Shafqat, SA Salameh, J Kashir… - Frontiers in …, 2022 - frontiersin.org
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), which causes
coronavirus-19 (COVID-19), has caused significant morbidity and mortality globally. In …

The dynamic changes in cytokine responses in COVID-19: a snapshot of the current state of knowledge

M Buszko, JH Park, D Verthelyi, R Sen, HA Young… - Nature …, 2020 - nature.com
“The role of cytokines in COVID-19” online symposium was presented on 18 June 2020 by
the NIH/FDA Immunology and Cytokine Interest Groups and was purposed to discuss our …

Mass cytometry reveals a conserved immune trajectory of recovery in hospitalized COVID-19 patients

CE Burnett, TLH Okholm, I Tenvooren, DM Marquez… - Immunity, 2022 - cell.com
While studies have elucidated many pathophysiological elements of COVID-19, little is
known about immunological changes during COVID-19 resolution. We analyzed immune …

Fighting COVID-19 exhausts T cells

C Moon - Nature Reviews Immunology, 2020 - nature.com
Acute respiratory distress syndrome (ARDS) and robust cytokine storm are the hallmark of
severe COVID-19 cases. Using single-cell RNA sequencing of bronchoalveolar lavage fluid …

Endothelial dysfunction contributes to severe COVID-19 in combination with dysregulated lymphocyte responses and cytokine networks

L Ruhl, I Pink, JF Kühne, K Beushausen… - Signal transduction and …, 2021 - nature.com
The systemic processes involved in the manifestation of life-threatening COVID-19 and in
disease recovery are still incompletely understood, despite investigations focusing on the …

The cytokine storm in COVID-19: Further advances in our understanding the role of specific chemokines involved

F Coperchini, L Chiovato, G Ricci, L Croce… - Cytokine & Growth …, 2021 - Elsevier
SARS-COV-2 infection represents the greatest pandemic of the world, counting daily
increasing number of subjects positive to the virus and, sadly, increasing number of deaths …