Alzheimer's disease: a matter of blood–brain barrier dysfunction?

A Montagne, Z Zhao, BV Zlokovic - Journal of Experimental Medicine, 2017 - rupress.org
The blood–brain barrier (BBB) keeps neurotoxic plasma-derived components, cells, and
pathogens out of the brain. An early BBB breakdown and/or dysfunction have been shown in …

[HTML][HTML] Addressing blood–brain barrier impairment in Alzheimer's disease

C Sharma, H Woo, SR Kim - Biomedicines, 2022 - mdpi.com
The blood–brain barrier (BBB) plays a vital role in maintaining the specialized
microenvironment of the brain tissue. It facilitates communication while separating the …

[HTML][HTML] Blood–Brain Barrier Breakdown in Alzheimer's Disease: Mechanisms and Targeted Strategies

AE Alkhalifa, NF Al-Ghraiybah, J Odum… - International Journal of …, 2023 - mdpi.com
The blood–brain barrier (BBB) is a unique and selective feature of the central nervous
system's vasculature. BBB dysfunction has been observed as an early sign of Alzheimer's …

[HTML][HTML] Blood–brain barrier breakdown: an emerging biomarker of cognitive impairment in normal aging and dementia

B Hussain, C Fang, J Chang - Frontiers in neuroscience, 2021 - frontiersin.org
The blood–brain barrier (BBB) plays a vital role in maintaining the specialized
microenvironment of the neural tissue. It separates the peripheral circulatory system from the …

[HTML][HTML] Reconsidering the role of blood-brain barrier in Alzheimer's disease: From delivery to target

JA Sousa, C Bernardes, S Bernardo-Castro… - Frontiers in aging …, 2023 - frontiersin.org
The existence of a selective blood-brain barrier (BBB) and neurovascular coupling are two
unique central nervous system vasculature features that result in an intimate relationship …

Blood–brain barrier dysfunction as a cause and consequence of Alzheimer's disease

MA Erickson, WA Banks - Journal of Cerebral Blood Flow & …, 2013 - journals.sagepub.com
The blood–brain barrier (BBB) plays critical roles in the maintenance of central nervous
system (CNS) homeostasis. Dysfunction of the BBB occurs in a number of CNS diseases …

Dysfunction of the blood–brain barrier in Alzheimer's disease: evidence from human studies

C Kurz, L Walker, BS Rauchmann… - Neuropathology and …, 2022 - Wiley Online Library
The pathological processes leading to synapse loss, neuronal loss, brain atrophy and
gliosis in Alzheimer's disease (AD) and their relation to vascular disease and immunological …

[HTML][HTML] Blood-brain barrier dysfunction and the pathogenesis of Alzheimer's disease

Y Yamazaki, T Kanekiyo - International journal of molecular sciences, 2017 - mdpi.com
Brain capillary endothelial cells form the blood-brain barrier (BBB), which is covered with
basement membranes and is also surrounded by pericytes and astrocyte end-feet in the …

Disruption of blood-brain barrier in Alzheimer disease pathogenesis

SY Kook, H Seok Hong, M Moon, I Mook-Jung - Tissue barriers, 2013 - Taylor & Francis
Blood-brain barrier (BBB) regulates transport of various molecules and maintains brain
homeostasis. Perturbed intracellular Ca2+ homeostasis and BBB damage have been …

Blood-brain barrier integrity in the pathogenesis of Alzheimer's disease

Z Huang, LW Wong, Y Su, X Huang, N Wang… - Frontiers in …, 2020 - Elsevier
The blood–brain barrier (BBB) tightly controls the molecular exchange between the brain
parenchyma and blood. Accumulated evidence from transgenic animal Alzheimer's disease …