Exposure to the drinking water contaminant arsenate is a daily occurrence and there are
concerns that this exposure may lead to cancer. Although the acute dispositional effects of …

Publisher Summary Groups of 90 female C57Bl/6J mice and 140 female metallothioein
knock-out transgenic (MT−) mice were given drinking water containing sodium arsenate …

Arsenic (As) is a metal found in nature whose acute and chronic toxic effects have been
known for decades. Hundreds of millions of people are at risk of exposure to As and its …

The metabolism of arsenic compounds in rats was studied by comparing urinary metabolites
of arsenic compounds administered for 1 wk or 7 mo. Male F344/DuCrj rats were given 100 …

The relationship of exposure and tissue concentration of parent chemical and metabolites
over prolonged exposure is a critical issue for chronic toxicities mediated by metabolite (s) …

Arsenic is carcinogenic in human beings, and environmental exposure to arsenic is a public
health issue that affects large populations worldwide. Thus, studies are needed to determine …

Exposure to the human carcinogen inorganic arsenic (iAs) occurs daily. However, the
disposition of arsenic after repeated exposure is not well known. This study examined the …

Several chronic bioassays have been conducted in multiple strains of mice in which various
concentrations of arsenate or arsenite were administered in the drinking water without a …

Abstract Dose-Dependent Disposition of Sodium Arsenate in Mice Following Acute Oral
Exposure. Hughes, MF, Menache, M., and Thompson, DJ (1994). Fundam. Appl. Toxicol. 22 …

After a single oral dose of sodium [74As] arsenate to male Wistar rats, arsenic was rapidly
absorbed and accumulated in the blood and to a lesser extent in the liver, kidneys, lungs …