Novavax NVX-COV2373 triggers neutralization of Omicron sub-lineages

JN Bhiman, SI Richardson, BE Lambson, P Kgagudi… - Scientific reports, 2023 - nature.com
Abstract The SARS-CoV-2 Omicron (B. 1.1. 529) Variant of Concern (VOC) and its sub-
lineages (including BA. 2, BA. 4, BA. 5, BA. 2.12. 1) contain spike mutations that confer high …

Less neutralization evasion of SARS-CoV-2 BA. 2.86 than XBB sublineages and CH. 1.1

Y Hu, J Zou, C Kurhade, X Deng… - Emerging microbes & …, 2023 - Taylor & Francis
ABSTRACT The highly mutated BA. 2.86, with over 30 spike protein mutations in
comparison to Omicron BA. 2 and XBB. 1.5 variants, has raised concerns about its potential …

Broadly neutralizing human antibodies against Omicron subvariants of SARS-CoV-2

HL Chiang, KH Liang, RM Lu, TW Kuo, YL Lin… - Journal of Biomedical …, 2023 - Springer
Background The COVID-19 pandemic continues to pose a significant worldwide threat to
human health, as emerging SARS-CoV-2 Omicron variants exhibit resistance to therapeutic …

Antiviral and bivalent vaccine efficacy against an omicron XBB. 1.5 isolate

R Uraki, M Ito, M Kiso, S Yamayoshi… - The Lancet Infectious …, 2023 - thelancet.com
As of January 2023, SARS-CoV-2 subvariants BQ. 1 (a BA. 5 subvariant) and XBB (a BA. 2
subvariant) have replaced previously dominant omicro n variants globally, including BA. 5 …

Structural delineation and computational design of SARS-CoV-2-neutralizing antibodies against Omicron subvariants

S Moriyama, Y Anraku, S Taminishi, Y Adachi… - Nature …, 2023 - nature.com
SARS-CoV-2 Omicron subvariants have evolved to evade receptor-binding site (RBS)
antibodies that exist in diverse individuals as public antibody clones. We rationally selected …

Neutralization of SARS-CoV-2 BQ. 1.1, CH. 1.1, and XBB. 1.5 by breakthrough infection sera from previous and recent waves in China

X Wang, S Jiang, S Jiang, X Li, J Ai, K Lin, S Lv… - Cell Discovery, 2023 - nature.com
Dear Editor, Since its emergence in late 2021, the SARS-CoV-2 Omicron variant has
continued to evolve and given rise to numerous subvariants. Due to the high transmissibility …

[HTML][HTML] Alarming antibody evasion properties of rising SARS-CoV-2 BQ and XBB subvariants

Q Wang, S Iketani, Z Li, L Liu, Y Guo, Y Huang… - Cell, 2023 - cell.com
The BQ and XBB subvariants of SARS-CoV-2 Omicron are now rapidly expanding, possibly
due to altered antibody evasion properties deriving from their additional spike mutations …

[HTML][HTML] B. 1.617. 2 enters and fuses lung cells with increased efficiency and evades antibodies induced by infection and vaccination

P Arora, A Sidarovich, N Krüger, A Kempf, I Nehlmeier… - Cell reports, 2021 - cell.com
The Delta variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), B.
1.617. 2, emerged in India and has spread to over 80 countries. B. 1.617. 2 replaced B. 1.1 …

Limited neutralisation of the SARS-CoV-2 Omicron subvariants BA. 1 and BA. 2 by convalescent and vaccine serum and monoclonal antibodies

A Wilhelm, M Widera, K Grikscheit, T Toptan… - …, 2022 - thelancet.com
Summary Background In recent months, Omicron variants of SARS-CoV-2 have become
dominant in many regions of the world, and case numbers with Omicron subvariants BA. 1 …

In vitro activity of therapeutic antibodies against SARS-CoV-2 Omicron BA. 1, BA. 2 and BA. 5

F Touret, C Baronti, B Pastorino, PMS Villarroel… - Scientific Reports, 2022 - nature.com
The replacement of the Omicron BA. 1 variant of SARS-CoV-2 by the BA. 2 and the rapid
growth of the BA. 5 sub lineage, which have both different sets of mutations in the spike …