Objective: Children exposed to severe, chronic stress are vulnerable to mental and physical
health problems across the lifespan. To explain how these problems develop, the …

Childhood poverty has pervasive negative physical and psychological health sequelae in
adulthood. Exposure to chronic stressors may be one underlying mechanism for childhood …

Objective Dysregulation of autonomic nervous system and hypothalamic-pituitary-adrenal
(HPA) axis function is a putative intermediate phenotype linking childhood adversity (CA) …

BACKGROUND: There is mounting interest in the hypothesis that inflammation contributes
to the pathogenesis of depression and underlies depressed patients' vulnerability to …

Early-life stress is associated with increased vulnerability to physical and emotional health
problems across the lifespan. The recently developed neuroimmune network hypothesis …

Background Inflammation has been hypothesized to contribute to reward dysfunction across
psychiatric conditions, but little is known about this relationship in youth. Therefore, the …

Childhood poverty negatively impacts physical and mental health in adulthood. Altered brain
development in response to social and environmental factors associated with poverty likely …

Investigating the developmental sequelae of early life stress has provided researchers the
opportunity to examine adaptive responses to extreme environments. A large body of work …

Background: There is accumulating evidence on the negative impacts of childhood poverty
on physical and mental health. Previous work has suggested hyperactive neural response to …

Background Pro-inflammatory cytokines have been linked to depression, early childhood
trauma, and impairment in executive function in adults. Whether these links are present …