Regulatory T‐cells in alopecia areata

JJ Speiser, D Mondo, V Mehta… - Journal of cutaneous …, 2019 - Wiley Online Library
Background Alopecia areata (AA) is believed to have an autoimmune mechanism in which
the hair follicles are targeted by CD4+ and CD8+ lymphocytes. Studies investigating the …

Alopecia areata patients show deficiency of FOXP3+CD39+ T regulatory cells and clonotypic restriction of Treg TCRβ-chain, which highlights the …

FN Hamed, A Åstrand, M Bertolini, A Rossi… - PLoS …, 2019 - journals.plos.org
Alopecia areata (AA) is a hair loss disorder resulting from an autoimmune reaction against
hair follicles. T-helper 1 cells are a major contributor to this disorder, but little is known about …

Impaired inhibitory function of circulating CD4+ CD25+ regulatory T cells in alopecia areata

BS Shin, T Furuhashi, M Nakamura, K Torii… - Journal of …, 2013 - jdsjournal.com
Alopecia areata (AA) presents as patches of hair loss, and progresses to include the entire
scalp (alopecia totalis; AT) or all body regions (alopecia universaris; AU) in 7% of affected …

Induction of cellular immunity against hair follicle melanocyte causes alopecia

H Nagai, S Oniki, M Oka, T Horikawa… - Archives of dermatological …, 2006 - Springer
Alopecia areata (AA) is generally regarded as an organ-specific autoimmune disease.
Although it has been hypothesized that the autoimmunity is mediated by T cells and that hair …

The potential of regulatory T cell-based therapies for alopecia areata

S Wan, W Xu, B Xie, C Guan, X Song - Frontiers in Immunology, 2023 - frontiersin.org
Cytotoxic T lymphocyte has been a concern for the etiopathogenesis of alopecia areata
(AA), some recent evidence suggests that the regulatory T (Treg) cell deficiency is also a …

Serum thymus and activation‐regulated chemokine as disease activity and response biomarker in alopecia areata

S Inui, F Noguchi, T Nakajima… - The Journal of …, 2013 - Wiley Online Library
Serum thymus and activation‐regulated chemokine/CCL 17 (s TARC) is known as a good
indicator for atopic dermatitis severity. Herein, we investigate whether s TARC correlates …

Apoptosis resistance in peripheral blood lymphocytes of alopecia areata patients

M Zöller, KJ McElwee, M Vitacolonna… - Journal of …, 2004 - Elsevier
Alopecia areata (AA) is a putative, cell-mediated autoimmune disease of anagen stage hair
follicles. Inter-and intra-follicular lymphocytic infiltrates are associated with alopecia that may …

Effects of low-dose recombinant interleukin 2 to promote T-regulatory cells in alopecia areata

E Castela, F Le Duff, C Butori, M Ticchioni… - JAMA …, 2014 - jamanetwork.com
Importance An impaired inhibitory function of circulating CD4+ CD25+ regulatory T (Treg)
cells was reported to play a key role in alopecia areata (AA). We report the first use to our …

Imbalance of T‐helper 17 and regulatory T cells in patients with alopecia areata

YM Han, YY Sheng, F Xu, SS Qi, XJ Liu… - The Journal of …, 2015 - Wiley Online Library
There is mounting evidence that T helper (Th) 17 cells and regulatory T cells (Treg) play
parts in the pathogenesis of autoimmune disease. Hence, levels of these T‐cell subsets in …

Role of T helper 17 cells and T regulatory cells in alopecia areata: comparison of lesion and serum cytokine between controls and patients

SH Loh, HN Moon, BL Lew… - Journal of the European …, 2018 - Wiley Online Library
Background Alopecia areata (AA) is an organ‐specific autoimmune disease with T‐cell‐
mediated attack of hair follicle autoantigens. As T helper 17 (Th17) cells and T regulatory …