Optic neuritis is a common clinical manifestation of the chronic inflammatory CNS disease
multiple sclerosis that can result in persistent visual impairment caused by degeneration of …

Autoimmune optic neuritis (AON), a model of multiple sclerosis‐associated optic neuritis, is
accompanied by degeneration of retinal ganglion cells (RGCs) and optic nerve …

Optic neuritis is one of the most common clinical manifestations of multiple sclerosis (MS), a
chronic inflammatory disease of the CNS. High-dosage methylprednisolone treatment has …

Axonal destruction and neuronal loss occur early during multiple sclerosis, an autoimmune
inflammatory CNS disease that frequently manifests with acute optic neuritis. Available …

In patients with multiple sclerosis (MS), non-remitting deficits are mainly caused by axonal
and neuronal damage. We demonstrated previously that myelin oligodendrocyte …

Optic neuritis is an inflammatory disease of the optic nerve that often occurs in patients with
multiple sclerosis and leads to permanent visual loss mediated by retinal ganglion cell …

Background and Purpose Glutamate transmission is dysregulated in both multiple sclerosis
(MS) and experimental autoimmune encephalomyelitis (EAE), the animal model of MS. A …

Inflammatory demyelination and axonal injury of the optic nerve are hallmarks of optic
neuritis (ON), which often occurs in multiple sclerosis and is a major cause of visual …

Glutamate is an essential neurotransmitter in the CNS. However, at abnormally high
concentrations it becomes cytotoxic. Recent studies in our laboratory showed that glutamate …

Background Optic neuritis is an acute, demyelinating neuropathy of the optic nerve often
representing the first appreciable symptom of multiple sclerosis. Wallerian degeneration of …