Transcriptome profiling reveals new insights into the immune microenvironment and upregulation of novel biomarkers in metastatic uveal melanoma

Y Krishna, A Acha-Sagredo, D Sabat-Pośpiech… - Cancers, 2020 - mdpi.com
Simple Summary Uveal melanoma (UM) is a rare aggressive eye cancer. Although
treatment of the eye tumour is successful, about 50% of UM patients develop a relapse of …

The immune cell landscape of metastatic uveal melanoma correlates with overall survival

A Tosi, R Cappellesso, AP Dei Tos, V Rossi… - Journal of Experimental …, 2021 - Springer
Background Uveal melanoma (UM) represents the most common primary intra-ocular
malignancy in adults. Up to 50% of the patients develop distant metastases within 10 years …

Integrated analysis reveals the dysfunction of signaling pathways in uveal melanoma

S Sun, B Guo, L Xu, R Shi - BMC cancer, 2022 - Springer
Background Uveal melanoma (UM) is the most common primary intraocular malignancy with
a strong tendency to metastasize. The prognosis is poor once metastasis occurs. The …

[HTML][HTML] Immune profiling of uveal melanoma identifies a potential signature associated with response to immunotherapy

Y Qin, K Bollin, MP De MacEdo… - … for immunotherapy of …, 2020 - ncbi.nlm.nih.gov
Background To date, no systemic therapy, including immunotherapy, exists to improve
clinical outcomes in metastatic uveal melanoma (UM) patients. To understand the role of …

Machine learning and single-cell RNA sequencing reveal relationship between intratumor CD8+ T cells and uveal melanoma metastasis

S Chen, Z Tang, Q Wan, W Huang, X Li, X Huang… - Cancer Cell …, 2024 - Springer
Purpose Uveal melanoma (UM) is adults' most common primary intraocular malignant tumor.
It has been observed that 40% of patients experience distant metastasis during subsequent …

Bioinformatic Analysis Reveals Central Role for Tumor‐Infiltrating Immune Cells in Uveal Melanoma Progression

M Lachota, A Lennikov, KJ Malmberg… - Journal of …, 2021 - Wiley Online Library
Tumor‐infiltrating immune cells are capable of effective cancer surveillance, and their
abundance is linked to better prognosis in numerous tumor types. However, in uveal …

[HTML][HTML] Molecular characteristics of liver metastases from uveal melanoma

T Meir, R Dror, X Yu, J Qian, I Simon… - … & visual science, 2007 - arvojournals.org
purpose. The liver is the most common site of systemic metastases from uveal melanoma
(UM). Such metastases usually continue to develop despite the application of current …

Integrated single-cell and transcriptome sequencing analyses develops a metastasis-based risk score system for prognosis and immunotherapy response in uveal …

S Meng, T Zhu, Z Fan, Y Cheng, Y Dong… - Frontiers in …, 2023 - frontiersin.org
Background: Uveal melanoma (UM) is the most frequent ocular neoplasm with a strong
metastatic ability. The prognostic value of metastasis-associated genes (MAGs) of UM …

[HTML][HTML] Immunological analyses reveal an immune subtype of uveal melanoma with a poor prognosis

H Pan, L Lu, J Cui, Y Yang, Z Wang, X Fan - Aging (Albany NY), 2020 - ncbi.nlm.nih.gov
Uveal melanoma is an aggressive intraocular malignancy that often exhibits low
immunogenicity. Metastatic uveal melanoma samples frequently exhibit monosomy 3 or …

Proteomics of primary uveal melanoma: insights into metastasis and protein biomarkers

GF Jang, JS Crabb, B Hu, B Willard, H Kalirai… - Cancers, 2021 - mdpi.com
Simple Summary This study pursued the proteomic analysis of primary uveal melanoma
(pUM) for insights into the mechanisms of metastasis and protein biomarkers. Liquid …