Defective host defenses later in life are associated with changes in immune system activity.
The means to correct immune defects to ensure immunity in the elderly are undefined. In this …

Defective host defenses later in life are associated with changes in immune cell activities,
suggesting that age-specific considerations are needed in immunotherapy approaches. In …

The etiology and effect of age-related immune dysfunction in cancer is not completely
understood. Here we show that limited priming of CD8+ T cells in the aged tumor …

Dendritic cells (DCs) undergo continuous changes throughout life, and there is evidence
that elderly DCs have a reduced capacity to stimulate T cells, which may contribute to …

Cellular senescence is a stress response that activates innate immune cells, but little is
known about its interplay with the adaptive immune system. Here, we show that senescent …

Aging is associated with progressive loss of immune function, which parallels the rise in
cancer incidence. The etiology and impact of age-related CD8+ T cell dysfunction in cancer …

Aging induces profound alterations in host biology and correlates with unfavorable clinical
outcomes in age-related diseases such as cancer. While the pivotal role of the immune …

Decline in immune function and inflammation concomitantly develop with ageing. Here we
focus on the impact of this inflammatory environment on T cells, and demonstrate that in …

Highlights•How aging impacts the immune priming capabilities of dendritic cells is
complex.•Some studies show reduced function, while others show preserved DC priming …

CD4+ T cells regulate humoral and cell-mediated immune responses, which are
progressively impaired in aging, resulting in susceptibility to infections and cancer. Dendritic …